학술논문
a-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels
Document Type
Article
Author
Source
Molecular Biology of the Cell; August 2016, Vol. 27 Issue: 16 p2542-2553, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
Ion channel subunits typically assemble in the endoplasmic reticulum. a-SNAP orchestrates a unique assembly and calcium selectivity of Orai1 subunits into functional multimers. Dynamic assembly of Orai1 and its dependence on a-SNAP could enable localization of calcium signals and regulation of rate and amount of calcium influx.