학술논문
Saralasin Blocks the Effect of Angiotensin II and Extracellular Fluid Saline Expansion on the Na-K-ATPase Inhibitor Release in Rats
Document Type
Article
Source
Clinical and Experimental Hypertension; 1986, Vol. 8 Issue: 6 p997-1008, 12p
Subject
Language
ISSN
10641963; 15256006
Abstract
A low molecular weight substance which behaves like ouabain as inhibitor of brain membrane Na-K-ATPase and 3H-ouabain binding was found in plasma after saline expansion of extracellular fluid or angiotensin II infusion into the third brain ventricle in the rat. Intracerebroventricular infusion of angiotensin II antagonist, saralasin, blocks the increase of the Na-K-ATPase inhibitor produced by infusion of angiotensin II into the third ventricle or extracellular fluid saline expansion.