학술논문
The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial
Document Type
Article
Author
Burns, Daniel K.; Chiang, Carl; Welsh-Bohmer, Kathleen A.; Brannan, Stephen K.; Culp, Meredith; O'Neil, Janet; Runyan, Grant; Harrigan, Patrick; Plassman, Brenda L.; Lutz, Michael; Lai, Eric; Haneline, Stephen; Yarnall, David; Yarbrough, Deborah; Metz, Craig; Ponduru, Sridevi; Sundseth, Scott; Saunders, Ann M.; Dubois, Bruno; Cummings, Jeffrey; Doody, Rachelle; Lyketsos, Constantine; Reiman, Eric; Welsh-Bohmer, Kathleen A.; Welsh-Bohmer, Kathleen A.; Sano, Mary; Schneider, Lon; Craft, Suzanne; Espeland, Mark; Monsch, Andreas
Source
Alzheimer's & Dementia: Translational Research & Clinical Interventions; January 2019, Vol. 5 Issue: 1 p661-670, 10p
Subject
Language
ISSN
23528737
Abstract
Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease expression. Designing such trials in cognitively normal elderly individuals poses unique challenges.