학술논문
Regulation of PTP1B activation through disruption of redox-complex formation
Document Type
Article
Author
Source
Nature Chemical Biology; February 2020, Vol. 16 Issue: 2 p122-125, 4p
Subject
Language
ISSN
15524450; 15524469
Abstract
We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3ζ and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.