학술논문
Mechanisms of corneal drug penetration III: Modeling of molecular transport
Document Type
Article
Source
Journal of Pharmaceutical Sciences; January 1988, Vol. 77 Issue: 1 p24-26, 3p
Subject
Language
ISSN
00223549; 15206017
Abstract
A model relating the parameters of permeability coefficient in the cornea with partition coefficient and molecular weight of the penetrating species is presented. The development of the model is unique in that it includes the availability of a '‘pore’' pathway with the corresponding kinetic data to substantiate this premise. The "pore” pathway is applied to small hydrophilic compounds and assumes that an aqueous diffusional space is available for transport of these compounds. This is in contrast to an alternate "partitioning" mechanism which is the most probable route of transport for larger or more lipophilic entities. The model is consistent with published data from this and other laboratories.