학술논문
Loss of KDM1Ain GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome: a multicentre, retrospective, cohort study
Document Type
Article
Author
Chasseloup, Fanny; Bourdeau, Isabelle; Tabarin, Antoine; Regazzo, Daniela; Dumontet, Charles; Ladurelle, Nataly; Tosca, Lucie; Amazit, Larbi; Proust, Alexis; Scharfmann, Raphael; Mignot, Tiphaine; Fiore, Frédéric; Tsagarakis, Stylianos; Vassiliadi, Dimitra; Maiter, Dominique; Young, Jacques; Lecoq, Anne-Lise; Deméocq, Vianney; Salenave, Sylvie; Lefebvre, Hervé; Cloix, Lucie; Emy, Philippe; Dessailloud, Rachel; Vezzosi, Delphine; Scaroni, Carla; Barbot, Mattia; de Herder, Wouter; Pattou, François; Tétreault, Martine; Corbeil, Gilles; Dupeux, Margot; Lambert, Benoit; Tachdjian, Gérard; Guiochon-Mantel, Anne; Beau, Isabelle; Chanson, Philippe; Viengchareun, Say; Lacroix, André; Bouligand, Jérôme; Kamenický, Peter
Source
The Lancet Diabetes & Endocrinology; December 2021, Vol. 9 Issue: 12 p813-824, 12p
Subject
Language
ISSN
22138587; 22138595
Abstract
GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome is caused by aberrant expression of the GIP receptor in adrenal lesions. The bilateral nature of this disease suggests germline genetic predisposition. We aimed to identify the genetic driver event responsible for GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome.