학술논문
Cessation of Smoking Trial in the Emergency Department (COSTED): a multicentre randomised controlled trial
Document Type
Article
Author
Pope, Ian; Clark, Lucy V; Clark, Allan; Ward, Emma; Belderson, Pippa; Stirling, Susan; Parrott, Steve; Li, Jinshuo; Coats, Tim; Bauld, Linda; Holland, Richard; Gentry, Sarah; Agrawal, Sanjay; Bloom, Benjamin Michael; Boyle, Adrian A; Gray, Alasdair J; Morris, M Geraint; Livingstone-Banks, Jonathan; Notley, Caitlin
Source
Emergency Medicine Journal; 2024, Vol. 41 Issue: 5 p276-282, 7p
Subject
Language
ISSN
14720205; 14720213
Abstract
BackgroundSupporting people to quit smoking is one of the most powerful interventions to improve health. The Emergency Department (ED) represents a potentially valuable opportunity to deliver a smoking cessation intervention if it is sufficiently resourced. The objective of this trial was to determine whether an opportunistic ED-based smoking cessation intervention can help people to quit smoking.MethodsIn this multicentre, parallel-group, randomised controlled superiority trial conducted between January and August 2022, adults who smoked daily and attended one of six UK EDs were randomised to intervention (brief advice, e-cigarette starter kit and referral to stop smoking services) or control (written information on stop smoking services). The primary outcome was biochemically validated abstinence at 6 months.ResultsAn intention-to-treat analysis included 972 of 1443 people screened for inclusion (484 in the intervention group, 488 in the control group). Of 975 participants randomised, 3 were subsequently excluded, 17 withdrew and 287 were lost to follow-up. The 6-month biochemically-verified abstinence rate was 7.2% in the intervention group and 4.1% in the control group (relative risk 1.76; 95% CI 1.03 to 3.01; p=0.038). Self-reported 7-day abstinence at 6 months was 23.3% in the intervention group and 12.9% in the control group (relative risk 1.80; 95% CI 1.36 to 2.38; p<0.001). No serious adverse events related to taking part in the trial were reported.ConclusionsAn opportunistic smoking cessation intervention comprising brief advice, an e-cigarette starter kit and referral to stop smoking services is effective for sustained smoking abstinence with few reported adverse events.Trial registration numberNCT04854616.