학술논문
Short-Term Effects of Appropriate Empirical Antimicrobial Treatment with Ceftolozane/Tazobactam in a Swine Model of Nosocomial Pneumonia
Document Type
Article
Author
Motos, Ana; Li Bassi, Gianluigi; Pagliara, Francesco; Fernandez-Barat, Laia; Yang, Hua; Aguilera Xiol, Eli; Senussi, Tarek; Idone, Francesco A.; Travierso, Chiara; Chiurazzi, Chiara; Amaro, Rosanel; Yang, Minlan; Bobi, Joaquim; Rigol, Montserrat; Nicolau, David P.; Frigola, Gerard; Cabrera, Roberto; Ramirez, Jose; Pelosi, Paolo; Blasi, Francesco; Antonelli, Massimo; Artigas, Antonio; Vila, Jordi; Kollef, Marin; Torres, Antoni
Source
Antimicrobial Agents and Chemotherapy; 2021, Vol. 65 Issue: 2 pe01899-20-e01899-20, 200188022p
Subject
Language
ISSN
00664804; 10986596
Abstract
The rising frequency of multidrug-resistant and extensively drug-resistant (MDR/XDR) pathogens is making more frequent the inappropriate empirical antimicrobial therapy (IEAT) in nosocomial pneumonia, which is associated with increased mortality. We aim to determine the short-term benefits of appropriate empirical antimicrobial treatment (AEAT) with ceftolozane/tazobactam (C/T) compared with IEAT with piperacillin/tazobactam (TZP) in MDR Pseudomonas aeruginosapneumonia. Twenty-one pigs with pneumonia caused by an XDR P. aeruginosastrain (susceptible to C/T but resistant to TZP) were ventilated for up to 72 h.