부산대학교 도서관

Hematopoietic stem cell transplantation (HSCT) with umbilical cord blood (UCB) is primarily for pediatric patients, as UCB has insufficient cell dosage for adult HSCT. The use of biomimetic scaffolds amongst other methods has been investigated for ex vivoexpansion of UCB hematopoietic stem & progenitor cells (HSPC) prior to transplantation. One such scaffold that we identified is surface functionalized single walled carbon nanotubes (f-SWCNT). In this study, we report how HSPC survival, molecular changes &ex vivoexpansion are dependent on various surface functional group of the f-SWCNT. Furthermore cotransplantation of f-SWCNT expanded & non-expanded cells from the same UCB enhanced human cell engraftment in immunodeficient xenograft models.