학술논문
Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial
Document Type
Article
Author
Kalil, Andre C; Mehta, Aneesh K; Patterson, Thomas F; Erdmann, Nathaniel; Gomez, Carlos A; Jain, Mamta K; Wolfe, Cameron R; Ruiz-Palacios, Guillermo M; Kline, Susan; Regalado Pineda, Justino; Luetkemeyer, Anne F; Harkins, Michelle S; Jackson, Patrick E H; Iovine, Nicole M; Tapson, Victor F; Oh, Myoung-don; Whitaker, Jennifer A; Mularski, Richard A; Paules, Catharine I; Ince, Dilek; Takasaki, Jin; Sweeney, Daniel A; Sandkovsky, Uriel; Wyles, David L; Hohmann, Elizabeth; Grimes, Kevin A; Grossberg, Robert; Laguio-Vila, Maryrose; Lambert, Allison A; Lopez de Castilla, Diego; Kim, EuSuk; Larson, LuAnn; Wan, Claire R; Traenkner, Jessica J; Ponce, Philip O; Patterson, Jan E; Goepfert, Paul A; Sofarelli, Theresa A; Mocherla, Satish; Ko, Emily R; Ponce de Leon, Alfredo; Doernberg, Sarah B; Atmar, Robert L; Maves, Ryan C; Dangond, Fernando; Ferreira, Jennifer; Green, Michelle; Makowski, Mat; Bonnett, Tyler; Beresnev, Tatiana; Ghazaryan, Varduhi; Dempsey, Walla; Nayak, Seema U; Dodd, Lori; Tomashek, Kay M; Beigel, John H; Hewlett, Angela; Taylor, Barbara S; Bowling, Jason E; Serrano, Ruth C; Rouphael, Nadine G; Wiley, Zanthia; Phadke, Varun K; Certain, Laura; Imlay, Hannah N; Engemann, John J; Walter, Emmanuel B; Meisner, Jessica; Rajme, Sandra; Billings, Joanne; Kim, Hyun; Martinez-Orozco, Jose A; Bautista Felix, Nora; Elmor, Sammy T; Bristow, Laurel R; Mertz, Gregory; Sosa, Nestor; Bell, Taison D; West, Miranda J; Elie-Turenne, Marie-Carmelle; Grein, Jonathan; Sutterwala, Fayyaz; Gyun Choe, Pyoeng; Kyung Kang, Chang; El Sahly, Hana M; Rhie, Kevin S; Hussein, Rezhan H; Winokur, Patricia L; Mikami, Ayako; Saito, Sho; Benson, Constance A; McConnell, Kimberly; Berhe, Mezgebe; Dishner, Emma; Frank, Maria G; Sarcone, Ellen; Crouch, Pierre-Cedric B; Jang, Hannah; Jilg, Nikolaus; Perez, Katherine; Janak, Charles; Cantos, Valeria D; Rebolledo, Paulina A; Gharbin, John; Zingman, Barry S; Riska, Paul F; Falsey, Ann R; Walsh, Edward E; Branche, Angela R; Arguinchona, Henry; Arguinchona, Christa; Van Winkle, Jason W; Zea, Diego F; Jung, Jongtak; Song, Kyoung-Ho; Kim, Hong Bin; Dwyer, Jay; Bainbridge, Emma; Hostler, David C; Hostler, Jordanna M; Shahan, Brian T; Hsieh, Lanny; Amin, Alpesh N; Watanabe, Miki; Short, William R; Tebas, Pablo; Baron, Jillian T; Ahuja, Neera; Ling, Evelyn; Go, Minjoung; Yang, Otto O; Ahn, Jenny; Arias, Rubi; Rapaka, Rekha R; Hubbard, Fleesie A; Campbell, James D; Cohen, Stuart H; Thompson, George R; Chakrabarty, Melony; Taylor, Stephanie N; Masri, Najy; Lacour, Alisha; Lee, Tida; Lalani, Tahaniyat; Lindholm, David A; Markelz, Ana Elizabeth; Mende, Katrin; Colombo, Christopher J; Schofield, Christina; Colombo, Rhonda E; Guirgis, Faheem; Holodniy, Mark; Chary, Aarthi; Bessesen, Mary; Hynes, Noreen A; Sauer, Lauren M; Marconi, Vincent C; Moanna, Abeer; Harrison, Telisha; Lye, David C; Ong, Sean W X; Ying Chia, Po; Huprikar, Nikhil; Ganesan, Anuradha; Madar, Christian; Novak, Richard M; Wendrow, Andrea; Borgetti, Scott A; George, Sarah L; Hoft, Daniel F; Brien, James D; McLellan, Susan L F; Levine, Corri; Nock, Joy; Yen Tan, Seow; Shafi, Humaira; Chien, Jaime M F; Candiotti, Keith; Finberg, Robert W; Wang, Jennifer P; Wessolossky, Mireya; Utz, Gregory C; Chambers, Susan E; Stephens, David S; Burgess, Timothy H; Rozman, Julia; Hyvert, Yann; Seitzinger, Andrea; Osinusi, Anu; Cao, Huyen; Chung, Kevin K; Conrad, Tom M; Cross, Kaitlyn; El-Khorazaty, Jill A; Hill, Heather; Pettibone, Stephanie; Wierzbicki, Michael R; Gettinger, Nikki; Engel, Theresa; Lewis, Teri; Wang, Jing; Deye, Gregory A; Nomicos, Effie; Pikaart-Tautges, Rhonda; Elsafy, Mohamed; Jurao, Robert; Koo, Hyung; Proschan, Michael; Davey, Richard; Yokum, Tammy; Arega, Janice; Florese, Ruth
Source
The Lancet Respiratory Medicine; 20210101, Issue: Preprints
Subject
Language
ISSN
22132600; 22132619
Abstract
Functional impairment of interferon, a natural antiviral component of the immune system, is associated with the pathogenesis and severity of COVID-19. We aimed to compare the efficacy of interferon beta-1a in combination with remdesivir compared with remdesivir alone in hospitalised patients with COVID-19.