학술논문
Enhancing immunogenicity of HPV16 E7DNA vaccine by conjugating codon-optimized GM-CSF to HPV16 E7DNA
Document Type
Article
Source
Taiwanese Journal of Obstetrics and Gynecology; July 2021, Vol. 60 Issue: 4 p700-705, 6p
Subject
Language
ISSN
10284559
Abstract
To generate immunity against human papillomavirus (HPV), the use of a recombinant DNA vaccine to carry an appropriate target gene is a promising and cost-effective approach. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent immunomodulatory cytokine that enhances the efficacy of vaccines by promoting the development and prolongation of humoral and cellular immunity. In this study, we linked codon-optimized GM-CSF (cGM-CSF) to the HPV16 E7 sequence as fused protein and evaluated the immunogenic potential of this DNA vaccine.