학술논문
The therapeutic effect of tanshinone IIA in mouse astrocytes after treatment with Angiostrongylus cantonensisfifth-stage larval excretory-secretory products
Document Type
Article
Author
Source
Journal of Microbiology, Immunology and Infection; August 2023, Vol. 56 Issue: 4 p853-862, 10p
Subject
Language
ISSN
16841182
Abstract
Angiostrongylus cantonensisis an important food-borne zoonotic parasite that causes eosinophilic meningitis and meningoencephalitis in humans. Excretory-secretory products (ESPs) are valuable targets for studying host-parasite relationships. ESPs are composed of a variety of molecules that are used to penetrate defensive barriers and avoid immune attack of the host. Tanshinone IIA (TSIIA) is a vasoactive cardioprotective drug that is widely used in studies evaluating potential therapeutic mechanisms. In this study, we will evaluate the therapeutic effects of TSIIA in mouse astrocytes after A. cantonensisfifth-stage larvae (L5) ESPs treatment.