학술논문
Efficacy and safety of three antiretroviral therapy regimens started in pregnancy up to 50 weeks post partum: a multicentre, open-label, randomised, controlled, phase 3 trial
Document Type
Article
Author
Chinula, Lameck; Ziemba, Lauren; Brummel, Sean; McCarthy, Katie; Coletti, Anne; Krotje, Chelsea; Johnston, Benjamin; Knowles, Kevin; Moyo, Sikhulile; Stranix-Chibanda, Lynda; Hoffman, Risa; Sax, Paul E; Stringer, Jeffrey; Chakhtoura, Nahida; Jean-Philippe, Patrick; Korutaro, Violet; Cassim, Haseena; Fairlie, Lee; Masheto, Gaerolwe; Boyce, Ceejay; Frenkel, Lisa M; Amico, K Rivet; Purdue, Lynette; Shapiro, Roger; Mmbaga, Blandina Theophil; Patel, Faeezah; van Wyk, Jean; Rooney, James F; Currier, Judith S; Lockman, Shahin; Best, Brookie M.; Blanchette, Cheryl D; Browning, Renee; Jaliaah, Nagawa; Mirochnick, Mark; Murtaugh, William A.; Patras, Emmanuel; Whalen, Frances; Momper, Jeremiah D.; Ponatshego, Ponego L.; Tirelo, Lesedi; Seme, Boitshepo J.; Modise, Georginah O.; Raesi, Mpho S.; Budu, Marian E.; Ramogodiri, Moakanyi; Oliveira, Ricardo H.; Hofe, Cristina B; Fernandes de Abreu, Thalita; Pestanha, Lorena M.; João, Esaú; Sidi, Leon C.; Fuller, Trevon; Cruz, Maria L.S; Pinto, Jorge; Ferreira, Flãvia; Correa Jr, Mãrio; Romeiro, Juliana; Pilotto, Jose H.; Fernandes, Luis E.B.C; Moreira, Luiz F.; Gomes, Ivete M.; Naik, Shilpa; Nevrekar, Neetal; Mave, Vidya; Kinikar, Aarti; Horne, Elizea; Soma-Kasiram, Hamisha; Violari, Avy; Mathiba, Sisinyana R.; Nyati, Mandisa; Theron, Gerhard; de Jager, Jeanne; Rossouw, Magdel; Rossouw, Lindie; Hanley, Sherika; Desmond, Alicia C.; Gazu, Rosemary; Govender, Vani; Chalermchockcharoenkit, Amphan; Thamkhantho, Manopchai; Werarak, Peerawong; Rungmaitree, Supattra; Achalapong, Jullapong; Sitiritkawin, Lukkana; Cressey, Tim R.; Sukrakanchana, Pra-ornsuda; Aurpibul, Linda; Tongprasert, Fuanglada; Khamrong, Chintana; Kiattivej, Sopida; Wabwire, Deo; Kabugo, Enid; Maena, Joel; Nakayiwa, Frances; Ndyanabangi, Victoria; Nagaddya, Beatrice; Sekabira, Rogers; Ashaba, Justus; Mitchell, Charles D.; Drada, Adriana; Alvarez, Grace A.; Scott, Gwendolyn B.; Rathore, Mobeen; Mahmoudi, Saniyyah; Shabbir, Adnan; Maraqa, Nizar; Mandima, Patricia F.; Mutambanengwe, Mercy; Maonera, Suzen; Chareka, Gift; Nematadzira, Teacler; Chanaiwa, Vongai; Matubu, Taguma A.; Tamirepi, Kevin; Maturure, Sukunena; Mhembere, Tsungai; Vhembo, Tichaona; Chidemo, Tinashe; Whalen, Frances
Source
The Lancet HIV; June 2023, Vol. 10 Issue: 6 pe363-e374, 12p
Subject
Language
ISSN
24054704; 23523018
Abstract
Drugs taken during pregnancy can affect maternal and child health outcomes, but few studies have compared the safety and virological efficacy of different antiretroviral therapy (ART) regimens. We report the primary safety outcomes from enrolment up to 50 weeks post partum and a secondary virological efficacy outcome at 50 weeks post partum of three commonly used ART regimens for HIV-1.