학술논문
Rapid Fire Abstract session: assessment of systolic function: clinical perspectives and future directions
Document Type
Article
Author
Baron, T; Christersson, C; Hedin, EM; Johansson, K; Flachskampf, FA; Kosmala, W; Rojek, A; Przewlocka-Kosmala, M; Karolko, B; Mysiak, A; Marwick, TH; Sarvari, S I; Sitges, M; Sanz, M; Tolosana Viu, JM; Edvardsen, T; Stokke, TM; Mont, L; Bijnens, B; Garcia Martin, A; Moya-Mur, JL; Carbonell-San Roman, S-A; Rodriguez-Munoz, D; Garcia-Lledo, A; Jimenez-Nacher, JJ; Segura-De La Cal, T; Fernandez-Golfin, C; Zamorano-Gomez, JL; Dumitrescu, S I; Droc, I; Neagoe, G; Mocanu, I; Murgu, V; Savoiu, D; Crisan, I; Dragomir, D; Stamate, S C; Cristian, G; Galli, E; Fournet, M; Samset, E; Leclercq, C; Donal, E; Pagourelias, E; Vovas, G; Duchenne, J; Mirea, OC; Van Aelst, L; Claus, P; Delforge, M; Van Cleemput, J; Bogaert, J; Voigt, JU; Martinez Santos, P; Batlle Lopez, E; Vilacosta, I; De La Rosa Riestra, A; Sanchez Sauce, B; Jimenez Valtierra, J; Espana Barrio, E; Campuzano Ruiz, R; Alonso Bello, J; Perez Gonzalez, F
Source
European Journal of Echocardiography; December 2015, Vol. 16 Issue: Supplement 2 pS130-S130, 1p
Subject
Language
ISSN
15252167; 15322114
Abstract
Aims: To assess the frequency of left ventricular (LV) systolic function impairment using classical echocardiographic parameters and their changes over time in patients with acute myocardial infarction (MI) and initially normal left ventricular ejection fraction (LV-EF ≥52% in males or ≥54% in females). Methods: All 421 consecutive patients with MI included in the Relevance of Biomarkers for future risk of thromboembolic events in UnSelected post-myocardial infarction patients (REBUS) study underwent 2D- and Doppler echocardiography within 72 hours and at one year after admission. LV-EF,diastolic and systolic volumes (LVEDVi, LVESV), mitral annular plane systolic excursion (MAPSE) and global longitudinal strain (GLS) were measured and data on first 100 patients with preserved LV-EF were analyzed in this pilot study. Results: LV-EF remained preserved (LV-EF ≥52% in males or ≥54% in females) in 74.2% of the patients < 72 h after MI. Among these patients impaired GLS (absolute value < 20%) was observed in 96.0 % of patients and decreased MAPSE (<1.1cm (females), 1.3cm (males)) in 56.6 % of patients. LVEDVi and LVESVi remained within normal range in all the studied patients (≤61ml/m2 (females) or ≤74ml/m2 (males), and ≤24ml/m2 (females) or ≤ 31ml/m2 (males), respectively). During one-year follow up (in absolute numbers of delta mean ± SD) the GLS improved with 3.4 ± 3.0%, while LV-EF decreased with 5.0 ± 7.7%. Both LVEDVi and LVESVi increased with 11.7 ± 10.4 ml/m2 and 7.1 ± 6.4 ml/m2, respectively. P<0.001 for all the analyses. MAPSE remained unchanged during the follow up. Conclusion: In the majority of patients within 72 h after MI and preserved LV-EF, at least one marker of systolic function was impaired, with GLS being the most common one. During the one-year follow up GLS improved, while the traditional parameters such as EF, LVEDVi and LVESVi significantly deteriorated, although still remaining within the normal range.