학술논문
Ruthenium(II)-Catalyzed Chelation-Assisted Desulfitative Arylation of Benzo[h]quinolines with Arylsulfonyl Chlorides
Document Type
Article
Author
Source
Organic Letters; April 2022, Vol. 24 Issue: 14 p2601-2606, 6p
Subject
Language
ISSN
15237060; 15237052
Abstract
Herein, a novel chelation-assisted C–H arylation reaction of benzo[h]quinoline is described. This transformation, using [RuCl2(p-cymene)]2as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, featured simple reaction conditions, a broad substrate scope, and functional group tolerance. The successful application of some bioactive-molecule-based sulfonyl chlorides further highlighted the potential utility and importance of this desulfitative C–H arylation protocol.