학술논문
Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross‐Sectional Study
Document Type
Article
Author
Fernández‐Carballido, Cristina; Martín‐Martínez, María A.; García‐Gómez, Carmen; Castañeda, Santos; González‐Juanatey, Carlos; Sánchez‐Alonso, Fernando; García de Vicuña, Rosario; Erausquin‐Arruabarrena, Celia; López‐Longo, Javier; Sánchez, María D.; Corrales, Alfonso; Quesada‐Masachs, Estefanía; Chamizo, Eugenio; Barbadillo, Carmen; Bachiller‐Corral, Javier; Cobo‐Ibañez, Tatiana; Turrión, Ana; Giner, Emilio; Llorca, Javier; González‐Gay, Miguel A.; Gonzalez de Rabago, Eugenia; Blanco Morales, Elena Alonso; Fernández Lopez, J. Carlos; Oreiro Villar, Natividad; Atanes Sandoval, Antonio; Blanco García, Francisco J.; Alegre De Miquel, Cayetano; González Fernández, María J.; Codina, Ramón Huguet; Yoldi, Beatriz; Ramentol, Mercedes; Ávila, Gabriela; Marsal Barril, Sara; Steiner, Martina; Muñoz, Santiago; Gamero, Fernando; García Torón, José; Espino, Pilar; Ros, Inmaculada; Ibáñez, Mónica; Murillo, Claudia; Molina, Jesús Tornero; Sanmartí, Raimon; Berman, Horacio; Cabrera, Sonia; Ruiz, Virginia; Patón, Oscar Fontseré; Fernández Gutierrez, Benjamín; Abasolo, Lydia; Pina, Jose Manuel; Nolla, Joan M.; García Arias, Miriam; Uriarte‐Ecenarro, Mirem; García Vadillo, Jesús A.; Fernández Nebro, Antonio; Manrique Arija, Sara; Belmonte López, María Angeles; Ureña, Inmaculada; Irigoyen, María V.; Cagigal, Virginia Coret; Garrido, Daniel Pielfort; García Aparicio, Angel María; Belmonte Gómez, Rebeca; Bautista, Pastora Granados; Hernandez Sanz, Azucena; Manero, Francisco J.; Jimenez Zorzo, Fernando; Giménez Ubeda, Eugenio; Gracía, Jesús Marzo; Audera, Chesús Beltrán; Medrano, Marta; Pecondón, Ángela; Ojeda, Soledad; Quevedo, Juan Carlos; Francisco, Félix; Rodríguez Lozano, Carlos; Gerona, Delia; González Fernández, Carlos; Carreño, Luis; Monteagudo, Indalecio; Pino, Javier; Peiró, María Enriqueta; Fernández‐Carballido, Cristina; Senabre, José M.; Rosas, José C.; Rotés, Isabel; Moreno, Estefanía; Erra, Alba; Grado, Dolors; Calvo, Javier; Rueda, Amalia; Möller, Ingrid; Rodríguez, Isabel; Raya, Enrique; Morales, Pilar; Nieto, Ana; Jiménez, Inmaculada; Magro, Cesar; Ruibal Escribano, Ana; Expósito, Sergio Ros; Sánchez Nievas, Ginés; Navarro, Enrique Júdez; Sianes Fernández, Manuela; García Morales, María Angeles; Bastero, Isabel Labiano; Consuegra, Gloria García; Palmou, Natalia; Pardo, Silvia Martínez; Pujol, Manel; Alonso, Elena Riera; Salvador, Georgina; González Alvarez, Beatriz; Cantabrana, Alberto; Bustabad, Sagrario; Delgado, Esmeralda; Muñoz, Alejandro; Montero, Sergio Rodriguez; Jimenez, Luis María
Source
Arthritis Care and Research; June 2020, Vol. 72 Issue: 6 p822-828, 7p
Subject
Language
ISSN
2151464X; 15290123
Abstract
To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This was a cross‐sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0–27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and Pvalues. We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28‐ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = –0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.