학술논문
Nonsymmetrically Substituted Cyclic Urea HIV Protease Inhibitors
Document Type
Article
Author
Source
Journal of Medicinal Chemistry; December 5, 1997, Vol. 40 Issue: 25 p4079-4088, 10p
Subject
Language
ISSN
00222623; 15204804
Abstract
A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure−activity relationship (QSAR), and pharmacokinetics for the series will be discussed.