학술논문
HIV Protease Inhibitory Bis-benzamide Cyclic Ureas: A Quantitative Structure−Activity Relationship Analysis
Document Type
Article
Author
Source
Journal of Medicinal Chemistry; October 11, 1996, Vol. 39 Issue: 21 p4299-4312, 14p
Subject
Language
ISSN
00222623; 15204804
Abstract
A series of N,N-disubstituted cyclic urea 3-benzamides has been synthesized and evaluated for HIV protease inhibition and antiviral activity. Some of these benzamides have been shown to be potent inhibitors of HIV protease with Ki < 0.050 nM and IC90 < 20 nM for viral replication and, as such, may be useful in the treatment of AIDS. The synthesis and quantitative structure−activity relationship for this benzamide series will be discussed.