학술논문
Response to Haart and Gb Virus Type C Coinfection in a Cohort of Antiretroviral-Naive HIV-Infected Individuals
Document Type
Article
Author
Antonucci, Giorgio; Girardi, Enrico; Cozzi-Lepri, Alessandro; Capobianchi, Maria Rosaria; Morsica, Giulia; Pizzaferri, Paolo; Ladisa, Nicoletta; Sighinolfi, Laura; Chiodera, Alessandro; Solmone, Mariacarmela; Lalle, Eleonora; Ippolito, Giuseppe; Monforte, Antonella d'Arminio; Ancarani, F; Antinori, A; Antonucci, G; Bonasso, M; Bruno, R; Capobianchi, MR; Cargnel, A; Cozzi-Lepri, A; d'Arminio Monforte, A; Luca, A De; Galli, M; Gennero, L; Girardi, E; Lipani, F; Marino, N; Milazzo, L; Morsica, G; Narciso, P; Pizzaferri, P; Puoti, M; Santantonio, T; Verucchi, G; Montroni, M; Scalise, G; Braschi, MC; Prete, MS Del; Tirelli, U; Cinelli, R; Pastore, G; Ladisa, N; Suter, G Minafra. Bergamo: F; Arici, C; Chiodo, F; Colangeli, V; Fiorini, C; Coronado, O; Carosi, G; Cadeo, GP; Torti, C; Minardi, C; Bertelli, D; Rizzardini, G; Migliorino, G; Manconi, PE; Piano, P; Ferraro, T; Scerbo, A; Pizzigallo, E; D'Alessandro, M; Santoro, D; Pusterla, L; Carnevale, G; Galloni, D; Viganò, P; Mena, M; Ghinelli, F; Sighinolfi, L; Leoncini, F; Mazzotta, F; Pozzi, M; Caputo, S Lo; Angarano, G; Grisorio, B; Saracino, A; Ferrara, S; Grima, P; Tundo, P; Pagano, G; Cassola, G; Alessandrini, A; Piscopo, R; Toti, M; Chigiotti, S; Soscia, F; Tacconi, L; Orani, A; Perini, P; Scasso, A; Vincenti, A; Chiodera, F; Castelli, P; Scalzini, A; Fibbia, G; Moroni, M; Lazzarin, A; Cargnel, A; Vigevani, GM; Caggese, L; Monforte, A d'Arminio; Repetto, D; Novati, R; Galli, A; Merli, S; Pastecchia, C; Moioli, MC; Esposito, R; Mussini, C; Abrescia, N; Chirianni, A; Izzo, CM; Piazza, M; Marco, M De; Viglietti, R; Manzillo, E; Graf, M; Colomba, A; Abbadessa, V; Prestileo, T; Mancuso, S; Ferrari, C; Pizzaferri, P; Filice, G; Minoli, L; Bruno, R; Novati, S; Baldelli, F; Tinca, M; Petrelli, E; Cioppi, A; Alberici, F; Ruggieri, A; Menichetti, F; Martinelli, C; Stefano, C De; Gala, A La; Ballardini, G; Briganti, E; Magnani, G; Ursitti, MA; Arlotti, M; Ortolani, P; Cauda, R; Dianzani, F; Ippolito, G; Antinori, A; Antonucci, G; D'Elia, S; Narciso, P; Petrosillo, N; Vullo, V; Luca, A De; Giambenedetti, S Di; Zaccarelli, M; Acinapura, R; Longis, P De; Ciardi, M; D'Offizi, G; Trotta, MP; Noto, P; Lichtner, M; Capobianchi, MR; Girardi, E; Pezzotti, P; Rezza, G; Mura, MS; Mannazzu, M; Resta, F; Loso, K; Caramello, P; Sinicco, A; Soranzo, ML; Orofino, G; Sciandra, M; Bonasso, M; Grossi, PA; Basilico, C; Poggio, A; Bottari, G; Raise, E; Pasquinucci, S; Lalla, F De; Tositti, G; Lepri, A Cozzi
Source
Antiviral Therapy; January 2005, Vol. 10 Issue: 1 p109-117, 9p
Subject
Language
ISSN
13596535
Abstract
The prognostic role of GB virus type C (GBV-C) viraemia in HIV-infected subjects treated with highly active antiretroviral therapy (HAART) is still undefined, The aim of this analysis is to assess the relationship between GBV-C infection and response to antiretroviral therapy among HIV-infected subjects initiating HAART when antiretroviral-naive.A prospective, observational study of 400 HIV-infected patients with measurements of GBV-C RNA, hepatitis C virus (HCV) antibodies and HCV RNA determined from plasma stored prior to HAART initiation, Time to virological (achieving HIV RNA =500 copies/ml) and immunological success (a CD4+ count increase of =200cells/µl), and the time to virological relapse (confirmed HIV RNA >500 copies/ml) were assessed by Kaplan-Meier methods and Cox proportional hazard regression model.Of the subjects, 117 (29.3%) were GBV-C positive and, overall, 351 (87.8%) patients achieved virological success, After controlling for a number of confounders including HCV RNA, GBV-C viraemic patients experienced a significantly lower risk of HIV rebound than those who were GBV-C negative [relative hazard (RH)=0.56, 95% CI: 0.34–0.93, P=0.03], Conversely, the probability of achieving initial virological success or CD4+ count response after HAART did not differ between GBV-C-negative and -positive subjects, These results suggest that GBV-C coinfection may play a role in determining the rate of HIV rebound possibly by competing with HIV replication after HIV load has been successfully suppressed by HAART.