부산대학교 도서관

Basic differences in the diagnosis and management of acute rejection in renal transplant can be found between centers. A questionnaire was developed to ascertain the profile of these variables. Sixteen fundamental questions were presented to the program directors of 17 transplant groups from around the world. The questions were brief and designed to identify clinical practice and behaviors related to the definition of acute and steroid-resistant rejection, successful response to therapy, use of histological diagnosis, estimated frequency of rejection, and frequency of mild, moderate, or severe acute rejections. Clinicians were presented with case studies and asked to respond to specific questions regarding the rejection management described in these cases to determine similarities in management practices. Results indicated that clinicians relied on clinical symptoms only rarely. Biopsy findings were used by 53% of clinicians, and 94% of clinicians indicated that rejection was suspected if creatinine increased. Successful response was defined as a return to prerejection creatinine level by 77% of clinicians and that steroid- resistant rejection is evident by 5 days. Biopsy was used by 80% of centers to diagnose first acute rejection episode, and only 18% of rejection episodes are expected to be severe. This report was then used to develop a more detailed questionnaire to be used in profiling acute rejection in consecutive transplant recipients. (Am J Kidney Dis 1998 Jun;31(6 Suppl 1):S26-30)