학술논문
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study
Document Type
Article
Author
Burtness, Barbara; Harrington, Kevin J; Greil, Richard; Soulières, Denis; Tahara, Makoto; de Castro, Gilberto; Psyrri, Amanda; Basté, Neus; Neupane, Prakash; Bratland, Åse; Fuereder, Thorsten; Hughes, Brett G M; Mesía, Ricard; Ngamphaiboon, Nuttapong; Rordorf, Tamara; Wan Ishak, Wan Zamaniah; Hong, Ruey-Long; González Mendoza, René; Roy, Ananya; Zhang, Yayan; Gumuscu, Burak; Cheng, Jonathan D; Jin, Fan; Rischin, Danny; Lerzo, Guillermo; Tatangelo, Marcelo; Varela, Mirta; Zarba, Juan Jose; Boyer, Michael; Gan, Hui; Gao, Bo; Hughes, Brett; Mallesara, Girish; Rischin, Danny; Taylor, Anne; Burian, Martin; Fuereder, Thorsten; Greil, Richard; Barrios, Carlos Henrique; de Castro Junior, Dalvaro Oliveira; Castro, Gilberto; Franke, Fabio Andre; Girotto, Gustavo; Lima, Iane Pinto Figueiredo; Nicolau, Ulisses Ribaldo; Pinto, Gustavo Dix Junqueira; Santos, Lucas; Victorino, Ana-Paula; Chua, Neil; Couture, Felix; Gregg, Richard; Hansen, Aaron; Hilton, John; McCarthy, Joy; Soulieres, Denis; Ascui, Rodrigo; Gonzalez, Pablo; Villanueva, Luis; Torregroza, Marco; Zambrano, Angela; Holeckova, Petra; Kral, Zdenek; Melichar, Bohuslav; Prausova, Jana; Vosmik, Milan; Andersen, Maria; Gyldenkerne, Niels; Jurgens, Hannes; Putnik, Kadri; Reinikainen, Petri; Gruenwald, Viktor; Laban, Simon; Aravantinos, Gerasimos; Boukovinas, Ioannis; Georgoulias, Vassilis; Psyrri, Amanda; Kwong, Dora; Al-Farhat, Yousuf; Csoszi, Tibor; Erfan, Jozsef; Horvai, Geza; Landherr, Laszlo; Remenar, Eva; Ruzsa, Agnes; Szota, Judit; Billan, Salem; Gluck, Iris; Gutfeld, Orit; Popovtzer, Aron; Benasso, Marco; Bui, Simona; Ferrari, Vittorio; Licitra, Lisa; Nole, Franco; Fujii, Takashi; Fujimoto, Yasushi; Hanai, Nobuhiro; Hara, Hiroki; Matsumoto, Koji; Mitsugi, Kenji; Monden, Nobuya; Nakayama, Masahiro; Okami, Kenji; Oridate, Nobuhiko; Shiga, Kiyoto; Shimizu, Yasushi; Sugasawa, Masashi; Tahara, Makoto; Takahashi, Masanobu; Takahashi, Shunji; Tanaka, Kaoru; Ueda, Tsutomu; Yamaguchi, Hironori; Yamazaki, Tomoko; Yasumatsu, Ryuji; Yokota, Tomoya; Yoshizaki, Tomokazu; Kudaba, Iveta; Stara, Zinaida; Wan Ishak, Wan Zamaniah; Cheah, Soon Keat; Aguilar Ponce, Jose; Gonzalez Mendoza, Rene; Hernandez Hernandez, Carlos; Medina Soto, Francisco; Buter, Jan; Hoeben, Ann; Oosting, S.; Suijkerbuijk, Karijn; Bratland, Aase; Brydoey, Marianne; Alvarez, Renzo; Mas, Luis; Caguioa, Priscilla; Querol, John; Regala, Eugenio Emmanuel; Tamayo, Maria Belen; Villegas, Ellie May; Kawecki, Andrzej; Karpenko, Andrey; Klochikhin, Arkadiy; Smolin, Alexey; Zarubenkov, Oleg; Goh, Boon Cher; Cohen, Graham; du Toit, Johanna; Jordaan, Christa; Landers, Gregory; Ruff, Paul; Szpak, Waldemar; Tabane, Neonyana; Brana, Irene; Iglesias Docampo, Lara; Lavernia, Javier; Mesia, Ricard; Abel, Edvard; Muratidu, Valentina; Nielsen, Niels; Cristina, Valerie; Rordorf, Tamara; Rothschild, Sacha; Hong, Ruey-Long; Wang, Hung-Ming; Yang, Muh-Hwa; Yeh, Su-Peng; Yen, Chia-Jui; Ngamphaiboon, Nuttapong; Soparattanapaisarn, Nopadol; Sriuranpong, Virote; Aksoy, Sercan; Cicin, Irfan; Ekenel, Meltem; Harputluoglu, Hakan; Ozyilkan, Ozgur; Harrington, Kevin; Agarwala, Sanjiv; Ali, Haythem; Alter, Robert; Anderson, Daniel; Bruce, Justine; Burtness, Barbara; Campbell, Nicholas; Conde, Miguel; Deeken, John; Edenfield, William; Feldman, Lawrence; Gaughan, Elizabeth; Goueli, Basem; Halmos, Balazs; Hegde, Upendra; Hunis, Brian; Jotte, Robert; Karnad, Anand; Khan, Saad; Laudi, Noel; Laux, Douglas; Martincic, Danko; McCune, Steven; McGaughey, Dean; Misiukiewicz, Krzysztof; Mulford, Deborah; Nadler, Eric; Neupane, Prakash; Nunnink, Johannes; Ohr, James; O'Malley, Meaghan; Patson, Brian; Paul, Doru; Popa, Elizabeta; Powell, Steven; Redman, Rebecca; Rella, Vincent; Rocha Lima, Chaio; Sivapiragasam, Abirami; Su, Yungpo; Sukari, Ammar; Wong, Stuart; Yilmaz, Emrullah; Yorio, Jeffrey
Source
The Lancet; November 2019, Vol. 394 Issue: 10212 p1915-1928, 14p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell death ligand 1 (PD-L1) expression associated with improved response.