학술논문
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
Document Type
Article
Author
Heerspink, Hiddo J L; Parving, Hans-Henrik; Andress, Dennis L; Bakris, George; Correa-Rotter, Ricardo; Hou, Fan-Fan; Kitzman, Dalane W; Kohan, Donald; Makino, Hirofumi; McMurray, John J V; Melnick, Joel Z; Miller, Michael G; Pergola, Pablo E; Perkovic, Vlado; Tobe, Sheldon; Yi, Tingting; Wigderson, Melissa; de Zeeuw, Dick; Elbert, Alicia; Vallejos, Augusto; Alvarisqueta, Andres; Maffei, Laura; Juncos, Luis; de Arteaga, Javier; Greloni, Gustavo; Farias, Eduardo; Zucchini, Alfredo; Vogel, Daniel; Cusumano, Ana; Santos, Juan; Fraenkel, Margaret; Gallagher, Martin; Davis, Tim; Acharya, Shamasunder; Cooke, Duncan; Suranyi, Michael; Roger, Simon; Toussaint, Nigel; Pollock, Carol; Chan, Doris; Stranks, Stephen; MacIsaac, Richard; Endre, Zoltan; Schmidt, Alice; Prager, Rudolf; Mayer, Gert; Warling, Xavier; Jadoul, Michel; Hougardy, Jean; Vercammen, Chris; Van Vlem, Bruno; Gillard, Pieter; Costa e Forti, Adriana; Borges, Joao Lindolfo; Santos Canani, Luis; Eliaschewitz, Freddy; Leite, Silmara; Fraige Filho, Fadlo; Paschoalin, Raphael; Moura Neto, Jose Andrade; Deboni, Luciane; de Lourdes Noronha, Irene; Cercato, Cintia; Prompt, Carlos Alberto; Zanella, Maria; Rassi, Nelson; D'Avila, Domingos; Milagres, Rosangela; Felicio, Joao; Pecoits Filho, Roberto; Riella, Miguel Carlos; Salles, Joao; Keitel, Elizete; Draibe, Sergio; Amodeo, Celso; Youmbissi, Joseph; Roy, Louise; Cournoyer, Serge; Jolly, Shivinder; Pichette, Vincent; Nesrallah, Gihad; Bajaj, Harpreet Singh; Khandwala, Hasnain; Aronson, Ronnie; Goluch, Richard; Tam, Paul; Rabbat, Christian; Tobe, Sheldon; Bailey, Gordon; Chow, Stephen; Castillo, Alvaro; Danin Vargas, Alfredo; Gonzalez, Fernando; Munoz, Rodrigo; Gutierrez, Vicente; Godoy, Gonzalo; Zhao, Hongwen; Liu, Zhangsuo; Zhao, Minghui; Guo, Xiaohui; Su, Benli; Fu, Shuxia; Xu, Yan; Yang, Jinkui; Shi, Bingyin; Xiao, Guanqing; Shi, Wei; Hao, Chuanming; Xing, Changying; Hou, Fanfan; Luo, Qun; Li, Yuxiu; Ji, Linong; Zuo, Li; Wang, Song; Ni, Zhaohui; Ding, Guohua; Chen, Nan; Zhao, Jiajun; Jia, Weiping; Yu, Shengqiang; Weng, Jian; Xu, Gang; Fu, Ping; Sun, Shiren; Liu, Bicheng; Ding, Xiaoqiang; Rychlik, Ivan; Oplustilova, Alexandra; Bartaskova, Dagmar; Honova, Vaclava; Chmelickova, Hana; Petr, Martin; Bucek, Petr; Tesar, Vladimir; Zahumensky, Emil; Povlsen, Johan; Egstrup, Kenneth; Oczachowska-Kulik, Anna; Rossing, Peter; Lahtela, Jorma; Strand, Jorma; Kantola, Ilkka; Petit, Catherine; Combe, Christian; Zaoui, Philippe; Esnault, Vincent; Urena Torres, Pablo; Halimi, Jean-Michel; Dussol, Bertrand; Bieler, Tasso; Budde, Klemens; Dellanna, Frank; Segiet, Thomas; Kosch, Christine; Schmidt-Guertler, Hans; Schenkenberger, Isabelle; Vielhauer, Volker; Pistrosch, Frank; Alscher, Mark; Hasslacher, Christoph; Hugo, Christian; Muehlfeld, Anja; Wanner, Christoph; Passadakis, Ploumis; Apostolou, Theofanis; Tentolouris, Nikolaos; Stefanidis, Ioannis; Mavromatidis, Konstantinos; Liakopoulos, Vasilios; Goumenos, Dimitrios; Siamopoulos, Konstantinos; Yeung, Vincent; Ozaki, Risa; Fung, Samuel; Tan, Kathryn; Tang, Sydney; Lui, Sing Leung; Cheung, Siu Fai; Sreenan, Seamus; Eustace, Joseph; O'Shea, Donal; Lavin, Peter; Stack, Austin; Yagil, Yoram; Wainstein, Julio; Knobler, Hilla; Cohen, Josef; Kenis, Irina; Daoud, Deeb; Bar-Dayan, Yosefa; Frajewicki, Victor; Adawi, Faiad; Gesualdo, Loreto; Santoro, Domenico; Marino, Francesco; Galfre, Andrea; Brunati, Chiara; Ruggenenti, Piero; Rombola, Giuseppe; Pugliese, Giuseppe; Ravera, Maura; Malberti, Fabio; Pontoriero, Giuseppe; Rampino, Teresa; De Cosmo, Salvatore; Esposito, Ciro; Nappi, Felice; Abaterusso, Cataldo; Conte, Giuseppe; Panichi, Vincenzo; Lauro, Davide; Capasso, Giovambattista; Russo, Domenico; Anzai, Jiichi; Naka, Motoji; Ato, Keita; Tsujimoto, Tetsuro; Nimura, Toshinori; Nakashima, Eitaro; Takeda, Tetsuro; Fujii, Shinya; Kobayashi, Kunihisa; Iwaoka, Hideaki; Nagayama, Koji; Harada, Hiroyuki; Maeda, Hajime; Kishimoto, Rui; Iitsuka, Tadashi; Itabashi, Naoki; Furuya, Ryuichi; Maeda, Yoshitaka; Yamada, Daishiro; Sasaki, Nobuhiro; Sasaki, Hiromitsu; Ueda, Shinichiro; Kashihara, Naoki; Watanabe, Shuichi; Nakamura, Takehiro; Kanai, Hidetoshi; Makita, Yuichiro; Ono, Keiko; Iehara, Noriyuki; Goto, Daisuke; Kosuge, Keiichiro; Tsuchida, Kenichi; Sato, Toshiaki; Sekikawa, Takashi; Okamoto, Hideki; Tanaka, Tsuyoshi; Ikeda, Naoko; Tadika, Takenobu; Mukasa, Koji; Osonoi, Takeshi; Hirano, Fuminori; Nishimura, Motonobu; Yambe, Yuko; Tanaka, Yukio; Ujihara, Makoto; Sakai, Takashi; Imura, Mitsuo; Umayahara, Yutaka; Makino, Shinya; Nakazawa, Jun; Yamaguchi, Yukinari; Kashine, Susumu; Miyaoka, Hiroaki; Suzuki, Katsunori; Inoue, Toshihiko; Nagai, Sou; Sato, Nobuyuki; Yamamoto, Masahiro; Taya, Noriyasu; Fujita, Akira; Matsutani, Akira; Shibagaki, Yugo; Sato, Yuichi; Yamauchi, Akira; Tsutsui, Masahiro; Ishiko, Tamayo; Kaneko, Shizuka; Azuma, Nobuyuki; Matsuda, Hirofumi; Hashiguchi, Yasuhiro; Onishi, Yukiko; Tokui, Mikiya; Matsuhisa, Munehide; Kiyosue, Arihiro; Shinoda, Junji; Ishikawa, Kazuo; Ahmad, Ghazali; Vijayasingham, Shalini; Aziz, Nor Azizah; Hussein, Zanariah; Fung, Yin Khet; Hassan, Wan Hasnul Halimi Wan; Wong, Hin Seng; Goh, Bak Leong; Ali, Norhaliza Mohd; Merican, Nor Shaffinaz Yusuf Azmi; Vaithilingam, Indralingam; Nik Ahmad, Nik Nur Fatnoon; Adam, Noor; Sukor, Norlela; Vengadasalam, V Paranthaman P; Abdul Kadir, Khalid; Mohamed, Mafauzy; Renoirte Lopez, Karina; Leguizamo-Dimas, Aniceto; Chew Wong, Alfredo; Chevaile-Ramos, Jose; Gonzalez Gonzalez, Jose; Rico Hernandez, Raul; Nino-Cruz, Jose; Sauque Reyna, Leobardo; Gonzalez-Galvez, Guillermo; Madero Rovalo, Magdalena; Bochicchio-Ricardelli, Tomasso; Aldrete, Jorge; Carranza-Madrigal, Jaime; Vogt, Liffert; Smak Gregoor, Peter; Barendregt, JNM; Luik, Peter; Gansevoort, Ronald; Laverman, Gozewijn; Pilmore, Helen; Lunt, Helen; Baker, John; Miller, Steven; Rabindranath, Kannaiyan; Zapata-Rincon, Luis; Vargas-Gonzales, Rolando; Calderon Ticona, Jorge; Dextre Espinoza, Augusto; Burga Nunez, Jose; Zea-Nunez, Carlos Antonio; Herrada Orue, Benjamin; Medina-Santander, Boris; Delgado-Butron, Cesar; Farfan-Aspilcueta, Julio; Mazur, Stanislaw; Necki, Miroslaw; Wruk, Michal; Klodawska, Katarzyna; Popenda, Grazyna; Skokowska, Ewa; Arciszewska, Malgorzata; Wiecek, Andrzej; Ciechanowski, Kazimierz; Nowicki, Michal; Birne, Rita; Cabrita, Antonio; Ramos, Aura; Antunes Ferreira, Manuel Anibal; Matta Fontanet, Evelyn; Alcantara-Gonzalez, Altagracia Aurora; Comulada-Rivera, Angel; Galindo Ramos, Eugenia; Cangiano, Jose; Quesada-Suarez, Luis; Calderon Ortiz, Ricardo; Vazquez-Tanus, Jose; Burgos-Calderon, Rafael; Rosado, Carlos; Hancu, Nicolae; Pintilei, Ella; Mistodie, Cristina; Bako, Gabriel; Ionutiu, Lavinia; Petrica, Ligia; Timar, Romulus; Tuta, Liliana; Duma, Livia; Tutescu, Adriana; Ivanova, Svetlana; Essaian, Ashot; Zrazhevskiy, Konstantin; Tomilina, Natalia; Smolyarchuk, Elena; Kuzin, Anatoly; Lantseva, Olga; Karpova, Irina; Shamkhalova, Minara; Liberanskaya, Natalia; Yavdosyuk, Andrey; Shvarts, Yuri; Bardymova, Tatiana; Blagoveshchenskaya, Olga; Solovev, Oleg; Rechkova, Elena; Pikalova, Natalia; Pavlova, Maria; Kolmakova, Elena; Sayfutdinov, Rustam; Villevalde, Svetlana; Koziolova, Natalya; Martynenko, Vladimir; Marasaev, Vyacheslav; Maksudova, Adelya; Sigitova, Olga; Mordovin, Viktor; Klimontov, Vadim; Samoylova, Yulia; Karonova, Tatiana; Yeoh, Lee Ying; Teo, Boon Wee; Foo, Marjorie Wai Yin; Liew, Adrian; Tkac, Ivan; Oroszova, Aniko; Fekete, Jozef; Rosenberger, Jaroslav; Obetkova, Ida; Fulopova, Alla; Kolesarova, Eva; Raslova, Katarina; Smolko, Peter; Oksa, Adrian; Distiller, Larry; Trokis, Julien; Adams, Luthando; Makan, Hemant; Ramlachan, Padaruth; Mitha, Essack; Coetzee, Kathleen; Punt, Zelda; Bhorat, Qasim; Naiker, Puvenesvari; Ellis, Graham; Van Zyl, Louis; Lee, Kwan Woo; Kim, Min Seon; Yoo, Soon-Jib; Yoon, Kun Ho; Cho, Yong-Wook; Park, Tae-Sun; Kim, Sang Yong; Choi, Moon-Gi; Oh, Tae Keun; Lee, Kang-Wook; Shon, Ho Sang; Suh, Sung Hwan; Kim, Byung-Joon; Doo-Man, Kim; Yi, Joo Hark; Lee, Sang Ah; Cho, Ho Chan; Kim, Sin-Gon; Cha, Dae-Ryong; Seo, Ji A; Choi, Kyung Mook; Woo, Jeong-Taek; Ahn, Kyu Jeung; Lee, Jae Hyuk; Kim, In-Joo; Lee, Moon-Kyu; Jang, Hak Chul; Park, Kyong-Soo; Kim, Beom Seok; Mok, Ji Oh; Shin, Mijung; Yoon, Sun Ae; Nam-Goong, Il-Seong; Chung, Choon Hee; Yu, Tae Yang; Lee, Hyoung Woo; Soto Gonzalez, Alfonso; Almirall, Jaume; Egido, Jesus; Calero Gonzalez, Francesca; Fernandez Fresnedo, Gema; Valera Cortes, Ildefonso; Praga Terente, Manuel; Garcia Mendez, Isabel; Navarro Gonzalez, Juan; Herrero Calvo, Jose; Cigarran Guldris, Secundino; Prieto Velasco, Mario; Minguela Pesquera, Jose Ignacio; Galan, Antonio; Pascual, Julio; Marques Vidas, Maria; Martins Munoz, Judith; Rodriguez-Perez, Jose; Castro-Alonso, Cristina; Bonet Sol, Josep; Seron, Daniel; Fernandez Giraldez, Elvira; Arrieta Lezama, Javier; Montero, Nuria; Hernandez-Jaras, Julio; Santamaria Olmo, Rafael; Molas Coten, Jose Ramon; Hellberg, Olof; Fellstrom, Bengt; Bock, Andreas; Pei, Dee; Lin, Ching-Ling; Tien, Kai-Jen; Chen, Ching-Chu; Huang, Chien-Ning; Jiang, Ju-Ying; Wu, Du-An; Chu, Chih-Hsun; Tseng, Shih-Ting; Chen, Jung-Fu; Bau, Cho-Tsan; Sheu, Wayne; Wu, Mai-Szu; Sari, Ramazan; Sezer, Siren; Yildiz, Alaattin; Satman, Ilhan; Kalender, Betul; Mankovskyy, Borys; Fushtey, Ivan; Stanislavchuk, Mykola; Kolenyk, Mykola; Dudar, Iryna; Zolotaikina, Viktoriia; Abrahamovych, Orest; Kostynenko, Tetyana; Petrosyan, Olena; Kuskalo, Petro; Galushchak, Olga; Legun, Oleg; Topchii, Ivan; Martynyuk, Liliya; Stryzhak, Vasyl; Panina, Svitlana; Tkach, Sergii; Korpachev, Vadym; Maxwell, Peter; Gnudi, Luigi; Kon, Sui Phin; Tindall, Hilary; Kalra, Phillip; Mark, Patrick; Patel, Dipesh; El-Shahawy, Mohamed; Bai, Liqun; Nica, Romanita; Lien, Yeong-Hau; Menefee, Judson; Busch, Robert; Miller, Alan; Ahmed, Azazuddin; Arif, Ahmed; Lee, Joseph; Desai, Sachin; Bansal, Shweta; Bentsianov, Marie; Belledonne, Mario; Jere, Charles; Gaona, Raul; Greenwood, Gregory; Brusco, Osvaldo; Boiskin, Mark; Belo, Diogo; Minasian, Raffi; Atray, Naveen; Lawrence, Mary; Taliercio, John; Pergola, Pablo; Scott, David; Alvarez, German; Marder, Bradley; Powell, Thomas; Bakdash, Wa'el; Stoica, George; McFadden, Christopher; Rendell, Marc; Wise, Jonathan; Jones, Audrey; Jardula, Michael; Madu, Ivy-Joan; Varghese, Freemu; Tulloch, Brian; Ahmed, Ziauddin; Hames, Melanie; Nazeer, Imran; Shahid, Newman; John, Rekha; Montero, Manuel; Fitz-Patrick, David; Phillips, Lawrence; Guasch, Antonio; Christofides, Elena; Gundroo, Aijaz; Amin, Mohammad; Bowman-Stroud, Cynthia; Link, Michael; Mulloy, Laura; Nammour, Michael; Lalwani, Tarik; Hanson, Lenita; Whaley-Connell, Adam; Herman, Lee; Chatha, Rupi; Osama, Sayed; Liss, Kenneth; Kayali, Zeid; Bhargava, Anuj; Israel, Ezra; Peguero-Rivera, Alfredo; Fang, Michael; Slover, Judith; Barengolts, Elena; Flores, Jose; Muoneke, Rosemary; Savin, Virginia; Awua-Larbi, Stella; Levine, Andrew; Newman, George; Golestaneh, Laden; Bohm, Guillermo; Reisin, Efrain; Cruz, Lucita; Weiss, Robert; Zieve, Franklin; Horwitz, Edward; Chuang, Peale; Mersey, James; Manley, John; Graf, Ronald; Bedros, Fadi; Joshi, Sudhir; Frias, Juan; Assefi, Ali; O'Shaughnessy, Andrew; Brantley, Roman; Minga, Todd; Tietjen, David; Kantor, Samuel; Jamal, Aamir; Guadiz, Ramon; Hershon, Kenneth; Bressler, Peter; Kopyt, Nelson; Cathcart, Harold; Bloom, Scott; Reichel, Ronald; Nakhle, Samer; Dulude, Emily; Tarkan, Joshua; Baker, Penelope; Zeig, Steven; Moya Hechevarria, Jaynier; Ropero-Cartier, Armando; De la Calle, Gilda; Doshi, Ankur; Saba, Fadi; Sligh, Teresa; Shaw, Sylvia; Kumar, Jayant; Szerlip, Harold; Bayliss, George; Perlman, Alan; Sakhrani, Lakhi; Gouge, Steven; Argoud, Georges; Acosta, Idalia; Elder, John; Joshi, Sucharit; Sensenbrenner, John; Vicks, Steven; Mangoo-Karim, Roberto; Galphin, Claude; Leon-Forero, Carlos; Gilbert, John; Brown, Eric; Ijaz, Adeel; Butt, Salman; Markell, Mariana; Arauz-Pacheco, Carlos; Sloan, Lance; Alvarado, Odilon; Jabbour, Serge; Simon, Eric; Rastogi, Anjay; James, Sam; Bakris, George; Hall, Karen; Melish, John; Dixon, Brad; Adolphe, Allen; Kovesdy, Csaba; Beddhu, Srinivasan; Solomon, Richard; Fernando, Ronald; Levin, Ellis; Thakar, Charuhas; Robey, Brooks; Goldfarb, David; Fried, Linda; Maddukuri, Geetha; Thomson, Stephen; Annand, Andrew; Kronfli, Saeed; Kalirao, Paramjit; Schmidt, Rebecca; Dahl, Neera; Blumenthal, Samuel; Weinstein, Debra; Ostergaard, Ove; Weinstein, Talia; Ono, Yasuhiro; Yalcin, Murat; Karim, Shahana
Source
The Lancet; May 2019, Vol. 393 Issue: 10184 p1937-1947, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.