학술논문
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial
Document Type
Article
Author
Roberts, Ian; Shakur-Still, Haleema; Afolabi, Adefemi; Akere, Adegboyega; Arribas, Monica; Brenner, Amy; Chaudhri, Rizwana; Gilmore, Ian; Halligan, Kenneth; Hussain, Irshad; Jairath, Vipul; Javaid, Kiran; Kayani, Aasia; Lisman, Ton; Mansukhani, Raoul; Mutti, Muttiullah; Arif Nadeem, Muhammad; Pollok, Richard; Simmons, Jonathan; Soomro, Majid; Stanworth, Simon; Veitch, Andrew; Hawkey, Christopher; Afolabi, Adefemi; Cuzick, Jack; Halligan, Kenneth; Henry, David; Metcalfe, Chris; Roberts, Ian; Gray, Richard; Barkun, Alan; David, Suresh; Devereaux, Philip; Brady, Tony; Roberts, Ian; Shakur-Still, Haleema; Coats, Timothy; Edwards, Phil; Gilmore, Ian; Jairath, Vipul; Ker, Katharine; Manno, Daniela; Stanworth, Simon; Veitch, Andrew; Arribas, Monica; Austin, Emma; Bal, Kiran; Balogun, Eni; Barrow, Collette; Beaumont, Danielle; Benyahia, Myriam; Brenner, Amy; Brooks, Imogen; Cargill, Madeleine; Carrington, Laura; Edwards, Phil; Frimley, Lauren; Geer, Amber; Gilbert, Daniel; Gilliam, Catherine; Gil Onandia, Julio; Golfi, Nayia; Hetherington, Daniel; Howe, Courtenay; Hughes, Carolyn; I'anson, David; Jackson, Rob; Joshi, Miland; Kansagra, Sneha; Kawahara, Taemi; Ker, Katharine; Kostrov, Sergey; Manno, Daniela; Mansukhani, Raoul; Miah, Hakim; Ndungu, Bernard; Needham, Kelly; Outtandy, Aroudra; Pearson, Daniel; Pepple, Tracey; Prowse, Danielle; Quashi, Nigel; Quinn, Anna; Ramos, Maria; Ranopa, Laura; Reid, Mia; Roberts, Ian; Roukas, Chris; Shakur-Still, Haleema; Squires, Chelci; Tanner, Jemma; Thayne, Andrew; Uddin, Ruhama; Chaudhri, Rizwana; Mutti, Muttiullah; Javaid, Kiran; Kayani, Aasia; Fawole, Bukola; Bello, Folasade Adenike; Olayemi, Oladapo; Afolabi, Adefemi; Okunade, Olujide; Adetayo, Olusade; Chaudhri, Rizwana; Mutti, Muttiullah; Afolabi, Adefemi; Bello, Folasade Adenike; Fawole, Bukola; Olayemi, Oladapo; Khamis, Hussein; Shukri Bin Jahit, Mohammad; Gogichaishvili, Tamar; Mateescu, Radu Bogdan; Adhikaree, Ajay; Abdo, Abdelmounem Eltayeib; Zaher, Mohammad; Deasy, Conor; Alvarez Gregori, Joaquin; Wellsh, Bobby; Lawton, Luke; Kamath, Raghavendra; Barry, Adrian; Carpio, Racquel; Finney, Kay; Maguire, Holly; James, Martin; Coffey, Frank; Gough, Chris; Sawers, Lisa; Thi, Aye-Aye; Simmons, Jonathan; Burnett, Claire; Jacques, Nicola; Murray, Victoria; Pollok, Richard; Jarman, Heather; Lambe, Christine; Rounding, Sarah; Tucker, Simon; Al-Idari, Romaih; Guest, Samuel; Stoddard, Emma; Yeo, David; Bergin, Colin; Hardy, Elaine; Thunder, Joanne; Jhalli, Paul; Hartley, Edward; Jarvis, Catherine; Swann, Carly; Reed, Matthew; Gallagher, Bernadette; Grahamslaw, Julia; O'Brien, Rachel; Harris, Timothy; Bellhouse, Geoffrey; Boulton, Olivia; Skene, Imogen; Stanley, Adrian; Johnstone, Janet; Maguire, Donogh; Thornton, Susan; Banks, Matthew; Bercades, Georgia; Marks, Daniel; Ryu, Jung; Harris, Timothy; Dowty, Claire; Pott, Jason; Skene, Imogen; East, James; Bailey, Adam; Beer, Sally; Davies, Sian; Appelboam, Andrew; Mackle, Daisy; Small, Jennifer; Vorwerk, Christiane; Atkins, Rachel; Bradbury, Isobel; Coats, Timothy; Bryceland, Catriona; McClelland, Lisa; Thomas, Martin; Clayton, Kate; Michael, Angiy; Haig, Stephen; Al-Nahhas, Saif; Godfrey, Tim; Boger, Philip; Comer, Rachel; Watkins, Barbara; Afolabi, Ola; Afzal, Shazad; Cowton, Amanda; Everett, Simon; Fazakerley, Ruth; Onoviran, Felicia; Snook, Jonathon; Berry, Jackie; Simpson, Diane; Keep, Jeff; Cotton, Hannah; Helyar, Sinead; Rutter, Matthew; Johnston, Tracey; O'Rourke, Laura; Chan, Louisa; Tambellini, Joanna; Trodd, Dawn; Shutt, James; Moreton, Sarah; Oglesby, Abby; Boyle, Adrian; Haeger, Nicola; Hardwick, Susie; Kendall, Jason; Faulkner, Beverley; Worner, Ruth; Hearnshaw, Sarah; Doona, Mary; Price, Maria; Hunter, Laura; Bell, Maggie; Loureiro, Vania; Kehoe, Anthony; Jefferey, Alison; Squire, Rosalyn; Hartin, David; Bell, Stephanie; Newman, Alexandra; Gagg, James; Foot, Jayne; Wakeford, Sue; May, Gabrielle; Bartram, Thomas; Cumpstay, Paul; Parker, Lucy; Das, Rita; Pahary, Sheik; Wright, Gavin; Butt, Georgina; Christmas, Natasha; Wilson, Sarah; Ashfaq, Mohammed; Chandler, Louise; Al-Nahhas, Saif; Demetriou, Carrie; Kaye, Philip; Carley, Simon; Brown, Andrew; Jones, Lucy; Whileman, Amanda; Greenaway, John; Tregonning, Julie; Harris, Timothy; Bellhouse, Geoffrey; Kuhrt, Avril; Goodacre, Steve; Jones, John; Owen, Charlotte; Mitra, Anu; Harper-Payne, Abby; Trudgill, Nigel; Hayes, Anne; Butt, Faheem; Clifford, Gayle; Kinnon, Andrew; Fowler, Susan; Pillay, Kris; Gidwani, Shweta; McNair, Alistair; Omer, Omer; de Weymarn, Tanya; Amin, Adnan; Chan, Louisa; Martin, Jane; Mathieu, Nick; Barnes, Simon; Turvill, James; Sweeting, Helen; Draegebo, Morten; McNaught, Marion; Grocutt, Mandy; Margalef, Jordi; Humphrey, Julian; Jackson, Richard; Bellis, Fionn; Hunt, Jane; Mitra, Anu; Stevenson, Alastair; Watson, Nicholas; Barden, Steven; Paterson, Stuart; Veitch, Andrew; Macdonald, Chris; Hobday, David; Orugun, Olu; Allison, Andrew; Dyer, Tristan; McBride, Samuel; Sawicki, Wojciech; Rayner, Ben; Flowerdew, Lynsey; Barbour, Jamie; Klein, Jason; Hood, Stephen; Palmer, Nicola; de Wolff, Jacob; Shenoy, Achuth; Trudgill, Nigel; Swallow, Peter; Srirajaskanthan, Rajaventhan; Hussain, Irshad; Arshad, Hamza; Aslam, Naeem; Bangash, Anam; Qamar, Muhammad; Zahoor, Haroon; Mutti, Muttiullah; Arshad, Saba; ain Ghalib, Quratul; Hameed, Tehseen; Saif, Tayyaba; Shafi, Wajahat; Arif Nadeem, Muhammad; Ali, Abid; Khan, Shehroze; Muaaz, Muhammad; Taj, Ahmad; Ghafoor, Aamir; Afridi, Aamir; Ahmad, Mansoor; Aslam, Mujahid; Kumar, Sandeep; Soomro, Majid; Ali, Mohsin; Bughio, Ubedullah; Chang, Adil; Shaikh, Sana; Ahmad, Syed; Ali, Zeeshan; Waqar, Marium; Mushir, Aiman; Sattar, Sadaf; Goraya, Saifullah; Aslam, Sharmeen; Fatima, Nighat; Noreen, Saadia; Saleem, Sheraz; Rahman, Fazal; Iqbal, Nadeem; Khalid, Mohammad; Riaz, Umar; Umar, Muhammad; Akhter, Tayyab; Khan, Javaria; Misbah, Noureen; Afzal, Muhammad; Kayani, Mobeen; Shah, Syed; Tarar, Shahida; Khan, Sherbat; Iqbal, Yasir; Khan, Essa; Reki, Maqbool; Hussain, Tanveer; Iqbal, Shafqat; Khurram, Muhammad; Shafi, Muhammad; Shaikh, Abrar; Ahmed, Aijaz; Kumar, Ameet; Sachdev, Pinkey; Nasir, Khalid Mahmood; Chaudhry, Zafar Iqbal; Zubair, Muhammad; Tayyab, Ghias; Mushtaq, Junaid; Nasir, Muhammad; Khan, Amir; Ali, Amjad; Ali, Sajjad; Uddin, Wasim; Ahmed, Sohaib; Kazmi, Tazaeen; Channa, Saleh; Aman, Adeeqa; Shaikh, Mouzam; Rizvi, Tahir; Hussain, Amjad; Baqai, Haider Zaigham; Rasheed, Zakawat; Khan, Abdus; Irfan, Adeela; Husain, Aamir; Aslam, Asifa; Yahya, Khalid; Azhar, Salman; Ul Haq, Mansoor; Afzal, Adeel; Imran, Muhammad; Saeed, Iram; Yusuf, Aasim; Hassan, Mariam; Marwat, Mumtaz; Ishfaq, Muhammad; Bashir, Tahir; Kumar, Santosh; Yaqoob, Sajjad; Wahid, Abdul; Akere, Adegboyega; Fakoya, Tinuola; Oke, Temitope; Tejan, Edries; Olaomi, Oluwole; Badejo, Olawale; Nnaemaka, Okafor; Ukwu, Nancy; Arowolo, Olukayode; Aderounmu, Adewale; Wuraola, Funmilola; Ugiagbe, Rose; Atiri, Alexander; Eghaghe, Enadeghe; Adekoya, Adeleke; Tade, Adedayo Oluyomi; Shonoiki, Olatunji; Olatoke, Samuel; Raji, Toafiq; Ekwunife, Christopher; Onyekpere, Chigozirim; Ahmed, Adamu; Muhammad, Daniyan; Odeghe, Emuobor; Lesi, Olufunmilayo; Osueni, Azeberoje; Samaila, Adamu; Nahuche, Aminu; Ajayi, Akande; Dongo, Andrew; Ijoma, Uchenna; Adebanjo, Ademola Tolulope; Igetei, Rufina; Yilkudi, Monday; Osisanya, Kehinde; Okeke, Edith Nonyelum; Enwere, Oguamanam Okezie; Esmat, Serag; Ashoush, Omar; Naga, Mazen; Nagy, Fady; Saiid, Mostafa; Shaker, Ahmed; Khamis, Hussein; Helmy, Ashraf; Saafan, Saafan; Abdel Monem, Mohammed; Din, Jiffre; Azis, Khairul; Brukan, Muhyuddin; Singh, Sanjay; Zakaria, Andee; Farid, Shaik; Hashim, Nizam; Mafauzy, Masykurin; Najmi, Wan; Amri, Nil; Yi, Xin; Hisyam, Mohammad; Ng, Elaine; Ramli, Zuhrirahimi; Yee Lim, Shyang; Voon, Kelvin; Young Yam, Sir; Jahit, Mohammad; Joon, Lee; Melikidze, Besik; Kazaishvili, Davit; Gogichaishvili, Tamar; Grubelashvili, Nino; Mosidze, Baadur; Tomadze, Gia; Megreladze, Avto; Oprita, Ruxandra; Pestroiu Calescu, Dorina; Chioncel, Camelia; Ragea, Andrei; Mateescu, Bogdan; Busuioc, Bogdan; Voiosu, Andrei; Cotirlet, Adrian; Pintilie, Iulia; Jinga, Mariana; Balaban, Daniel; Tanău, Marcel; Negreanu, Lucian; Bataga, Simona; Priya, Khushboo; Baral, Shankar; K.C., Anuj; Sah, Vijay; Yadav, Vijay; Adhikaree, Ajay; Abdo, Abdelmounem; Ahmed, Dalia; Al Anazi, Marzouqah; Al Balkhi, Areej; Deasy, Conor; Álvarez Gregori, Joaquín; Fornieles Pérez, Helio; Beqiri, Arben; Wellsh, Bobby; Lawton, Luke
Source
The Lancet; June 2020, Vol. 395 Issue: 10241 p1927-1936, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding.