학술논문
Rapid development of hepatic alpha1-antitrypsin globules after liver transplantation for chronic hepatitis C
Document Type
Article
Author
Source
Gastroenterology; April 1997, Vol. 112 Issue: 4 p1372-1375, 4p
Subject
Language
ISSN
00165085; 15280012
Abstract
A 37-year-old man undergoing liver transplantation for cirrhosis caused by chronic hepatitis C and alcoholism developed large numbers of alpha1- antitrypsin (AAT) globules within hepatocytes of the transplanted liver during a 5-month period. This finding occurred simultaneously with severe recurrent hepatitis C. The AAT phenotype of this patient changed from MM before transplantation to MZ after transplantation; AAT levels in serum did not change significantly. After a second liver transplantation 6 months after the first, the AAT phenotype reverted to MM and globules were not detectable in the second transplanted liver. Severe recurrent hepatitis C and the appearance of AAT globules within the liver allograft of a heterozygous donor may be related. The recurrent infection may have induced accumulation of AAT protein, or, alternatively, the MZ liver may have been more susceptible to injury from recurrent viral infection. (Gastroenterology 1997 Apr;112(4):1372-5)