학술논문
CTLA4Ig treatment in patients with multiple sclerosis
Document Type
Article
Author
Source
Neurology (Ovid); September 2008, Vol. 71 Issue: 12 p917-924, 8p
Subject
Language
ISSN
00283878; 1526632X
Abstract
The modulation of costimulatory pathways represents an original therapeutic approach to regulate T cell–mediated autoimmune diseases by preventing or reducing autoantigen-driven T-cell activation in humans. Autoreactive CD4T cells play a critical role in initiating the immune response leading to the chronic inflammation and demyelination characteristic of multiple sclerosis (MS).