부산대학교 도서관

Urinary ADH (antidiuretic hormone) excretion was determined in adrenalectomized rats which were given a 0.9 % NaCl sodium as drinking water. The animals were adrenalectomized and studied after either 4 or 7 days. In both cases, urinary ADH excretion was twice as high as in sham-operated rats indicating that adrenalectomy enhances ADH release. The ADH content of neurohypophyses (LN) was also measured in these rats: 4 days after adrenalectomy no alteration in the hormonal content could be detected, but an increase of 40 % occurred 7 days later. The accumulation of ADH in the neurohypophysis of these animals suggests that the hormonal synthesis is also increased after adrenalectomy and to a greater proportion than the amount of ADH released.Urinary ADH excretion returned to normal after administration of pharmacological doses of dexamethasone. Three days of dexamethasone treatment prevented the increase of ADH in neurohypophyses of rats which had been adrenalectomized 4 days before the start of the treatment.The effects of a glucocorticoid lack and of dexamethasone treatment on the synthesis and release of ADH are discussed; moreover a control of the effects of glucocorticoids on ADH synthesis has to be taken into consideration.