학술논문
Relationship between the in-situ activity of ornithine decarboxylase and contractile function of the rabbit papillary muscle
Document Type
Article
Author
Source
Basic Research in Cardiology; November 1983, Vol. 78 Issue: 6 p631-643, 13p
Subject
Language
ISSN
03008428; 14351803
Abstract
Summary The relationship between isometric contraction and myocardial ornithine decarboxylase (ODC; EC. 4.1.1.17) activity was studied in right ventricular papillary muscles isolated from rabbits. ODC specific activity and polyamine content were significantly increased in papillary muscles contracting isometrically 90 times per minute at the apex of the length-tension, relationship for 4 to 5 hours when compared with paired non-contracting muscles or isometrically contracting muscles stimulated at 30 times per min. The increase in ODC activity appeared to be due to new protein synthesis since cycloheximide blocked the increase in ODC activity without affecting isometric function. Thus, the present results suggest that increased contractile demands of the heart may stimulate the synthesis of myocardial ODC, increase ODC activity and polyamine content.