학술논문
Impact of donor kinship on non-T-cell depleted haploidentical stem cell transplantation with post transplantation cyclophosphamide for acute leukemia: From the ALWP of the EBMT
Document Type
Article
Author
Danylesko, Ivetta; Peczynski, Christophe; Labopin, Myriam; Polge, Emmanuelle; Tischer, Johanna; Blaise, Didier; Koc, Yener; Gülbas, Zafer; Ciceri, Fabio; Arat, Mutlu; Castagna, Luca; Bruno, Benedetto; Raiola, Anna Maria; Botella-Garcia, Carmen; Savani, Bipin N.; Piemontese, Simona; Ruggeri, Annalisa; Nagler, Arnon; Mohty, Mohamad
Source
Bone Marrow Transplantation; August 2022, Vol. 57 Issue: 8 p1260-1268, 9p
Subject
Language
ISSN
02683369; 14765365
Abstract
Non-T-cell depleted haploidentical hematopoietic cell transplantation (Haplo-HCT) is a unique transplantation setting in which several donors are available. We assessed the impact of donor kinship on outcome of Haplo-HCT with post-transplantation cyclophosphamide in a cohort of 717 acute leukemia patients. We compared sibling with parent donors in patients ≤45 years, and child with sibling donors in patients >45 years. Donor kinship was not associated with worse outcomes in multivariate analysis. For patients ≤45 years, the hazard ratio (HR) for leukemia-free survival (LFS), overall survival (OS), relapse incidence (RI), and chronic graft-versus-host disease (cGVHD) was 0.87 (p= 0.75), 1.19 (p= 0.7), 0.52 (p= 0.19), and 0.99 (p= 0.97) for parents versus siblings, respectively, and for patients >45 years the HR was 0.93 (p= 0.8), 0.98 (p= 0.94), 1.3 (p= 0.53), and 0.98 (p= 0.95) for children versus siblings, respectively. Univariate incidence of acute GVHD grade II-IV was significantly higher in patients transplanted from siblings versus children (p= 0.002). Factors associated with inferior outcome were advanced disease and earlier transplant. In patients ≤45 years, acute lymphocytic leukemia and peripheral blood stem cell graft were additional prognostic factors for OS. We did not find a significant impact of donor kinship on transplantation outcome when analyzing by age group (≤45 and >45 years).