학술논문
Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries
Document Type
Article
Author
Sharmin, Sifat; Roos, Izanne; Malpas, Charles B; Iaffaldano, Pietro; Simone, Marta; Filippi, Massimo; Kubala Havrdova, Eva; Ozakbas, Serkan; Brescia Morra, Vincenzo; Alroughani, Raed; Zaffaroni, Mauro; Patti, Francesco; Eichau, Sara; Salemi, Giuseppe; Di Sapio, Alessia; Inglese, Matilde; Portaccio, Emilio; Trojano, Maria; Amato, Maria Pia; Kalincik, Tomas; Horakova, Dana; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Boz, Cavit; Pozzilli, Carlo; Cocco, Eleonora; Gallo, Paolo; Yamout, Bassem; Khoury, Samia J.; Lugaresi, Alessandra; Onofrj, Marco; Lus, Giacomo; Clerici, Valentina Torri; Maniscalco, Giorgia Teresa; Romano, Silvia; Tortorella, Carla; Valentino, Paola; Rovaris, Marco; Shaygannejad, Vahid; Ferraro, Diana; Vianello, Marika; Grammond, Pierre; Bergamaschi, Roberto; Gallo, Antonio; Cavalla, Paola; Sa, Maria Jose; Lechner-Scott, Jeannette; Pesci, Ilaria; Buzzard, Katherine; Gouider, Riadh; Mrabet, Saloua; Aguglia, Umberto; Conte, Antonella; Avolio, Carlo; Bellantonio, Paolo; John, Nevin; Cartechini, Elisabetta; De Robertis, Francesca; Ferraro, Elisabetta; Weinstock-Guttman, Bianca; Barcella, Valeria; Van der Walt, Anneke; Butzkueven, Helmut; Coniglio, Maria Gabriella; Granella, Franco; Kuhle, Jens; Marfia, Girolama Alessandra; Laureys, Guy; Van Hijfte, Liesbeth; Maimone, Davide; Gazzola, Paola; Blanco, Yolanda; Turkoglu, Recai; Montepietra, Sara; Spitaleri, Daniele; van Pesch, Vincent; Gerlach, Oliver; Prevost, Julie; Ampapa, Radek; Soysal, Aysun; Altintas, Ayse; Rini, Augusto; Solaro, Claudio; Protti, Alessandra; Foschi, Matteo; Surcinelli, Andrea; Gatto, Maurizia; Mascoli, Nerina; De Riz, Milena; Realmuto, Sabrina; Rossi, Patrizia; Totaro, Rocco; Barnett, Michael; Oh, Jiwon; Nasuelli, Davide; Ramo-Tello, Cristina; Sanchez-Menoyo, Jose Luis; Al-Harbi, Talal; Fioretti, Cristina; Bucello, Sebastiano; Cargnelutti, Daniela; Vukusic, Sandra
Source
The Lancet Child & Adolescent Health; May 2024, Vol. 8 Issue: 5 p348-357, 10p
Subject
Language
ISSN
23524642; 23524650
Abstract
High-efficacy disease-modifying therapies have been proven to slow disability accrual in adults with relapsing–remitting multiple sclerosis. However, their impact on disability worsening in paediatric-onset multiple sclerosis, particularly during the early phases, is not well understood. We evaluated how high-efficacy therapies influence transitions across five disability states, ranging from minimal disability to gait impairment and secondary progressive multiple sclerosis, in people with paediatric-onset multiple sclerosis.