학술논문
Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study
Document Type
Article
Author
Orrell, Catherine; Hagins, Debbie P; Belonosova, Elena; Porteiro, Norma; Walmsley, Sharon; Falcó, Vicenç; Man, Choy Y; Aylott, Alicia; Buchanan, Ann M; Wynne, Brian; Vavro, Cindy; Aboud, Michael; Smith, Kimberly Y; Cahn, Pedro Enrique; Cassetti, Lidia Isabel; Porteiro Barreira, Norma; Angel, Jonathan Benjamin; de Pokomandy, Alexandra; Harris, Marianne; Rachlis, Anita R.; Walmsley, Sharon L.; Allavena, Clotilde; Bouchaud, Oliver; Gatey, Caroline; Rami, Agathe; Casari, Salvatore; Di Perri, Giovanni; Lazzarin, Adriano; Maggiolo, Franco; Penco, Giovanni; Quirino, Tiziana; Rizzardini, Giuliano; Andrade-Villanueva, Jaime-Federico; Sierra-Madero, Juan G.; Branco, Teresa; Serrao, Rosario; Teofilo, Eugenio JR.; Melendez-Rivera, Ivan; Santiago, Lizette; Zorrilla, Carmen D.; Belonosova, Elena; Chernova, Oksana E.; Pokrovsky, Vadim; Rakhmanova, Aza Gasanovna; Tsybakova, Olga; Voronin, Eugene; Orrell, Catherine; Vally, Tasneem; Farisani, Livhuwani ML.; Sebopa, Boitumelo Lucrecia; Barros, Carlos Aguado; Cano Sánchez, Alfredo; Castaño, Manuel; Falcó Ferrer, Vicens; González García, Juan J.; Hernandez-Quero, Jose; Negredo Puigmal, Eugenia; Pérez Elías, María Jesús; Podzamczer Palter, Daniel; Portilla, Joaquin Sogorb; Viciana Fernández, Pompeyo; Manosuthi, Weerawat; Ruxrungtham, Kiat; Dockrell, David H.; Hay, Phillip E.; Johnson, Margaret A.; Mackie, Nicola E.; Orkin, Chloe M.; Taylor, Steve; Bhatti, Laveeza; Brar, Indira; Brennan, Robert Owen; Cade, Jerry L.; Casanas, Beata; Casey, Kathleen; Cunningham, Douglas; DeJesus, Edwin; Dietz, Craig; Dretler, Robin Henry; Eron, Joseph J.; Felizarta, Franco Antoni B.; Fife, Kenneth H.; Hagins, Debbie P.; Hoffman-Terry, Margaret; Jain, Mamta; Johnson, Marc Alexander; Kinder, Clifford A.; Kumar, Princy N.; Lewis, Stanley T.; McDonald, Cheryl Kay; Meza, Armando D.; Mounzer, Karam C.; Newman, Cheryl L.; Osiyemi, Olayemi O.; Poblete, Ronald; Presti, Rachel M.; Ramgopal, Moti; Rosenstock, Joel; Samuel, Rafik; Sandkovsky, Uriel Sebastian; Shon, Alyssa So Young; Skiest, Daniel J.; Sloan, Louis M.; Small, Catherine B.; Tebas, Pablo; Van Dam, Cornelius N.
Source
The Lancet HIV; December 2017, Vol. 4 Issue: 12 pe536-e546, 11p
Subject
Language
ISSN
24054704; 23523018
Abstract
Dolutegravir is a once-daily integrase strand transfer inhibitor with no need for pharmacokinetic boosting that is approved for the treatment of HIV-1 infection. Because women are often under-represented in HIV clinical trials, we addressed the safety and efficacy of dolutegravir in women with HIV-1.