학술논문
Sotrovimab therapy elicits antiviral activities against Omicron BQ.1.1 and XBB.1.5 in sera of immunocompromised patients
Document Type
Article
Author
Bruel, Timothée; Vrignaud, Lou-Léna; Porrot, Françoise; Staropoli, Isabelle; Planas, Delphine; Guivel-Benhassine, Florence; Puech, Julien; Prot, Matthieu; Munier, Sandie; Bolland, William Henry; Soulié, Cathia; Zafilaza, Karen; Lusivika-Nzinga, Clovis; Meledge, Marie-Laure; Dorival, Céline; Molino, Diana; Péré, Hélène; Yordanov, Youri; Simon-Lorière, Etienne; Veyer, David; Carrat, Fabrice; Schwartz, Olivier; Marcelin, Anne-Geneviève; Martin-Blondel, Guillaume; Garcia, Magalie; Giraud, Valentin; Metais, Agathe; Cazenave-Roblot, Fance; Martellosio Anne-Marie Ronchetti, Jean-Philippe; Gabas, Thomas; Hadjadj, Naima; Salanoubat, Célia; Chabrol, Amélie; Housset, Pierre; Pardon, Agathe; Faucon, Anne-Laure; Caudwell, Valérie; Roland Liblau, Latifa Hanafi; Alric, Laurent; Pugnet, Grégory; Mourguet, Morgane; Bories, Eva; Bonnet, Delphine; Charpentier, Sandrine; Delobel, Pierre; Debard, Alexa; Beck, Colleen; Boumaza, Xavier; Fanny Lanternier, Stella Rousset; Delage, Claire; Pires, Elisabete Gomes; Cheminant, Morgane; Anthony Chauvin, Nathalie Chavarot; Véronique Delcey Simon Bessis, Xavier Eyer; Cresta, Mélanie; Pélagie Thibaut, Romain Gueneau; Nadal, Marine; Siguier, Martin; Bachir, Marwa; Valérie Pourcher, Christia Palacios; Melenotte, Cléa; Faycal, Antoine; Berot, Vincent; Brin, Cécile; Djebara, Siham; Zafilaza, Karen; Marot, Stéphane; Sayon, Sophie; Leducq, Vincent; Malet, Isabelle; Teyssou, Elisa; Karine Lacombe, Adélie Gothland; Aad, Yasmine Abi; Chiarabini, Thibault; Feliho, Raynald; Valin, Nadia; Brigant, Fabien; Boize, Julien; Thiébaud, Pierre-Clément; Moreau, Marie; Nathalie De Castro, Charlotte Billard; Liégeon, Geoffroy; Denis, Blandine; Molina, Jean-Michel; André Cabié, Lucia Etheve; Abel, Sylvie; Cabras, Ornella; Guitteaud, Karine; François Vincent Dubee, Sandrine Pierre-; Ndiaye, Diama; Pehlivan, Jonathan; Phelippeau, Michael; Alexandre Duvignaud, Rafael Mahieu; Pistone, Thierry; Desclaux, Arnaud; Neau, Didier; Jean-François Faucher, Charles Cazanave; Festou, Benjamin; Dupuy-Grasset, Magali; Loustaud-Ratti, Véronique; Nathan Peiffer- Smadja, Delphine Chainier; Choquet, Christophe; Da Conceicao, Olivia; Thy, Michael; Collas, Lio; Godard, Cindy; Bouzid, Donia; Ing, Vittiaroat; Pereira, Laurent; Pavlowsky, Thomas; RavautAntoine Asquier-Khati, Camille; Boutoille, David; Chauveau, Marie; Deschanvres, Colin; Audrey Le Bot, François Raffi; Cailleaux, Marine; Benezit, François; Maillard, Anne; Hue, Benoit; François Coustilleres, Pierre Tattevin; Carvalho-Schneider, Claudia; Jamard, Simon; Petit, Laeticia; Natacha Mrozek, Karl Stefic; Theis, Clément; Vidal, Magali; Sauvat, Léo; Benjamin Lefèvre, Delphine Martineau; Baronnet, Guillaume; Florence Ader, Agnès Didier; Perpoint, Thomas; Conrad, Anne; Chabert, Paul; Aurélie Martin, Pierre Chauvelot; Loubet, Paul; Mazet, Julien; Larcher, Romaric; Mathilde Devaux Jérôme Frey, Didier Laureillard; Woerlen, Amos; Remillon, Aline; Absensur-Vuillaume, Laure; Albert Trinh-Duc, Pauline Bouquet; Philippe Petua, Patrick Rispal; Aurore Perrot, Julien Carillo; Delavigne, Karen; Cougoul, Pierre; Dion, Jérémie; Mathieu Blot, Odile Rauzy; Sixt, Thibault; Moretto, Florian; Charles, Carole; Sophie Circosta, Lionel Piroth; Leger, Lydia; Arulananthan, Arulvani; Lascoux, Carine; Valérie, Pascaline; Yazdan Yazdanpanah, Leia Becam; Petrov-Sanchez, Ventzislava; Diallo, Alpha; Le Mestre, Soizic; Le Meut Isabelle Goderel, Guillaume; Chau, Frédéric; Soltana, Brahim; Chane Tang, Jessica; Guedj, Jérémie; Caille, Yvanie
Source
Med; October 2023, Vol. 4 Issue: 10 p664-667, 4p
Subject
Language
ISSN
26666340
Abstract
Antibodies effective against the recent Omicron sublineages are missing. By taking advantage of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to-moderate COVID-19, Bruel et al. show that administration of 500 mg of sotrovimab induces serum neutralization and antibody-dependent cellular cytotoxicity of BQ.1.1 and XBB.1.5. Therefore, sotrovimab may remain a therapeutic option against these variants.