학술논문
The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion
Document Type
Article
Author
Source
Molecular Biology of the Cell; April 2018, Vol. 29 Issue: 7 p834-845, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
This study provides novel mechanistic insights into how Syt-1 and Syt-7 C2B domains regulate the later stages of exocytosis. We show that small structural differences within this region exert significant effects on fusion pore properties. We propose that these effects may arise from differences in C2B domain affinity for the plasma membrane.