학술논문
Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
Document Type
Article
Author
Source
Drug Metabolism Letters; January 2008, Vol. 2 Issue: 1 p67-75, 9p
Subject
Language
ISSN
18723128
Abstract
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.