학술논문
Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance
Document Type
Article
Author
Holle, Johannes; Bartolomaeus, Hendrik; Löber, Ulrike; Behrens, Felix; Bartolomaeus, Theda U.P.; Anandakumar, Harithaa; Wimmer, Moritz I.; Vu, Dai Long; Kuhring, Mathias; Brüning, Ulrike; Maifeld, Andras; Geisberger, Sabrina; Kempa, Stefan; Schumacher, Fabian; Kleuser, Burkhard; Bufler, Philip; Querfeld, Uwe; Kitschke, Stefanie; Engler, Denise; Kuhrt, Leonard D.; Drechsel, Oliver; Eckardt, Kai-Uwe; Forslund, Sofia K.; Thürmer, Andrea; McParland, Victoria; Kirwan, Jennifer A.; Wilck, Nicola; Müller, Dominik
Source
Journal of the American Society of Nephrology; December 2022, Vol. 33 Issue: 12 p2259-2275, 17p
Subject
Language
ISSN
10466673; 15333450
Abstract
Controlling chronic inflammatory processes, which are a major risk factor for cardiovascular disease, is of outstanding importance in CKD to reduce the rate of CKD-associated morbidity. This investigation connects microbial dysbiosis and bacterial metabolite imbalance to a proinflammatory immune cell signature. The fact that these dysbiosis-driven immunologic changes are already detectable in children with CKD, in whom comorbidities usually found in adults are absent, highlights the importance and specificity of CKD-related microbiota-immune interaction for chronic inflammation. Personalized dietary interventions and microbiota-targeted therapies may be a promising area of research to improve the prognosis of young and old patients with CKD.