학술논문
Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial
Document Type
Article
Author
Peters, Mark J; Gould, Doug W; Ray, Samiran; Thomas, Karen; Chang, Irene; Orzol, Marzena; O'Neill, Lauran; Agbeko, Rachel; Au, Carly; Draper, Elizabeth; Elliot-Major, Lee; Giallongo, Elisa; Jones, Gareth A L; Lampro, Lamprini; Lillie, Jon; Pappachan, Jon; Peters, Sam; Ramnarayan, Padmanabhan; Sadique, Zia; Rowan, Kathryn M; Harrison, David A; Mouncey, Paul R; Thomas, Carla; Jirasek, Petr; Jones, Dawn; Dore, Rachael; O'Malley, Laura; Kanthimatinathan, Hari Krishnan; Winmill, Helen; Ashton, Lydia; Owen, Samantha; Davis, Peter; Marley-Munn, Helen; Moody, Francesca; Haskins, Ellen; Dodge, Laura; Jones, Andrew; Thomas, Joan; Murphy, Gail; Lillie, Jon; Williams, Aleks; Wellman, Paul; Aougah, Esther; Payne, Caroline; Belfield, Holly; Akpan, Joshua; Benkenstein, Sarah; Beech, Emily; Manjra, Ilham I; Hulme, Sara-Louise; Sarfatti, Avishay; Beadon, Kirsten; Harmer, Rebecca; Deep, Akash; Balnta, Christina; D'Silva, Pamela; Hylton, Asha; Saikia, Bedangshu; Nichani, Sanjiv; Patel, Rekha; Davies, Patrick; Anderson, Laura; Lawless, Laura; Dewar, Alex; Reynolds, David; Levin, Richard; Bowman, Fiona; Pujazon, Andrea-Rosa; Davidson, Mark; Szulik, Katarzyna; Bunni, Lara; Jennings, Claire; Marshall, Rebecca; Griksaitis, Michael; Thomas, Philippa; Postlethwaite, Catherine; Cook, Amber; Dwarakanathan, Buvana; Gomes de Queiroz, Joana; Ros Foguet, Montserrat; Ali, Hawakiin; Bycroft, Thomas; Darnell, Sarah; Mustafa, Sobia; Bridges, Katy; Mulgrew, Kirsty; Heenan, Nadine; Bell, Lynne; Davies, Andrew
Source
The Lancet; January-February 2024, Vol. 403 Issue: 10424 p355-364, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practiced, but has been associated with harm in paediatric patients. We aimed to evaluate whether conservative oxygenation would reduce duration of organ support or incidence of death compared to standard care.