학술논문
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma
Document Type
Article
Author
Zacarías-Fluck, Mariano F.; Massó-Vallés, Daniel; Giuntini, Fabio; González-Larreategui, Íñigo; Kaur, Jastrinjan; Casacuberta-Serra, Sílvia; Jauset, Toni; Martínez-Martín, Sandra; Martín-Fernández, Génesis; Serrano del Pozo, Erika; Foradada, Laia; Grueso, Judit; Nonell, Lara; Beaulieu, Marie-Eve; Whitfield, Jonathan R.; Soucek, Laura
Source
Genes & Development; 2023, Vol. 37 Issue: 7-8 p303-320, 18p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Zacarías-Fluck et al. report the use of Omomyc, a MYC inhibitor, in targeting melanoma development, metastasis, and recurrence in human cell lines and CDX mouse models. By blocking MYC's transcriptional influence, Omomyc elicited gene expression signatures associated with good patient prognoses, pointing to the therapeutic potential of MYC inhibition in melanoma.