학술논문
p53 induces formation of NEAT1lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
Document Type
Article
Author
Adriaens, Carmen; Standaert, Laura; Barra, Jasmine; Latil, Mathilde; Verfaillie, Annelien; Kalev, Peter; Boeckx, Bram; Wijnhoven, Paul W G; Radaelli, Enrico; Vermi, William; Leucci, Eleonora; Lapouge, Gaëlle; Beck, Benjamin; van den Oord, Joost; Nakagawa, Shinichi; Hirose, Tetsuro; Sablina, Anna A; Lambrechts, Diether; Aerts, Stein; Blanpain, Cédric; Marine, Jean-Christophe
Source
Nature Medicine; August 2016, Vol. 22 Issue: 8 p861-868, 8p
Subject
Language
ISSN
10788956; 1546170X
Abstract
Silencing expression of the long noncoding RNA NEAT1prevents paraspeckle formation and sensitizes neoplastic cells to DNA-damage-induced cell death. NEAT1expression also predicts chemotherapy response in ovarian cancer patients.