부산대학교 도서관

Background:Acute myocardial infarction (AMI) is one of the world's leading causes of cardiovascular death. Recent studies have reported the influence of the genes caveolin-3(CAV3), suppression of tumorigenicity 2, and growth differentiating factor-15in cardiovascular diseases, especially myocardial infarction, but their role and function remain unclear. Hence, this study was designed to evaluate the expression levels of these three genes in AMI and understanding the role of CAV-3in the pathogenesis of AMI.Methods and Results:Blood samples were collected from 50 AMI patients and 50 non-AMI controls in this cross-sectional study. Relative expression levels of the three genes were performed using real-time PCR. Bioinformatics tools were used for functional gene enrichment and protein-protein interactions. CAV-3was significantly upregulated among AMI patients compared to controls. In silicoanalyses identified CAV-3as playing critical roles in smooth muscle contraction, cardiac conduction, and calcium-mediated transport via binding with essential proteins including dysferlin and annexinsConclusion:This study is a first of its kind, reporting an upregulation of CAV-3in AMI patients. The expression of all three genes significantly influenced the systolic function of the heart in AMI patients. A more in-depth understanding of CAV-3in the pathophysiology of AMI is essential and it may prove to be a novel.