학술논문
Autophagy deficiency boosts the production of kojic acid in the filamentous fungus Aspergillus oryzae
Document Type
Article
Author
Source
Bioscience, Biotechnology, and Biochemistry; December 2021, Vol. 85 Issue: 12 p2429-2433, 5p
Subject
Language
ISSN
09168451; 13476947
Abstract
We found that the expression of genes involved in kojic acid (KA) biosynthesis, kojA, kojR, and kojT, was highly elevated in the Aspergillus oryzaeautophagy-deficient mutants. In agreement, KA production was much increased in these mutants. Nuclear translocation of KojR, a transcription factor, was observed in the autophagy mutants before they were starved, explaining why KA production was boosted.