학술논문
Stag2a or Stag2b Knockout Zebrafish Are Viable, Yet Loss of Stag2a Is Associated with Abnormal Expression of Early and Late Myeloid and Lymphoid Markers
Document Type
Article
Source
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p5708-5708, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Introduction:Mutations in Stromal antigen 2( STAG2)are frequently found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In mice, loss of Stag2 is embryonic lethal. Conditional knockout of Stag2in adult mice results in MDS-like hematopoietic anomalies. Zebrafish harbor two paralogues of STAG2( stag2aand stag2b). To date, a complete stag2-null zebrafish model organism has not been developed. Recently reported, a stag2b-/-zebrafish demonstrated downregulation in primitive erythropoiesis. However, any hematopoiesis beyond 2 days post fertilization (2 dpf) was not detailed. Furthermore, a stag2amutant zebrafish has not been reported.