학술논문
Reasons for antiretroviral switching in Colombia: A retrospective cohort study
Document Type
Article
Author
Valderrama-Beltrán, Sandra Liliana; Martínez-Vernaza, Samuel; Correa-Forero, Shirley Vanessa; Jaimes-Reyes, Maria Alejandra; Arévalo-Mora, Leonardo; Martínez-Buitrago, Ernesto; Franco, Julieta; Beltrán-Rodríguez, Claudia; Urrego-Reyes, Juan; Leon, Sebastian; García Garzon, Martha; Gonzalez, Claudia; Fonseca, Norberto; Botero, Monica; Andrade, Javier; Alzamora, Diana; Lenis, William; Pardo, José; Alzate-Ángel, Juan; Mantilla, Monica; Sussmann, Otto; Montero-Riascos, Leonardo; Álvarez-Moreno, Carlos Arturo
Source
International Journal of STD & AIDS; November 2023, Vol. 34 Issue: 13 p921-931, 11p
Subject
Language
ISSN
09564624; 17581052
Abstract
Introduction Long-term use of antiretroviral therapy (ART) for HIV infection might lead to the necessity of switching regimens. We aimed to analyze the reasons for the ART switch, the time-to-switch of ART, and its associated factors in a Colombian cohort.Methods We conducted a retrospective cohort in 20 HIV clinics, including participants ≥18 years old with confirmed HIV infection who underwent an ART switch from January 2017 to December 2019 with at least 6 months of follow-up. A time-to-event analysis and an exploratory Cox model were performed.Results 796 participants switched ART during the study period. The leading cause of ART switch was drug intolerance (n= 449; 56.4%) with a median time-to-switch of 12.2 months. The longest median time-to-switch was due to regimen simplification (42.4 months). People ≥50 years old (HR = 0.6; 95% CI (0.5–0.7) and CDC stage 3 at diagnosis (HR = 0.8; 95% CI (0.6–0.9) had less hazard for switching ART over time.Conclusions In this Colombian cohort, drug intolerance was the main cause of the ART switch, and the time-to-switch is shorter than reports from other countries. In Colombia, it is crucial to apply current recommendations for ART initiation to choose regimens with a better tolerability profile.