학술논문
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Document Type
Article
Author
Source
Genes & Development; 2021, Vol. 35 p1005-1019, 15p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Burgess et al. show that replication of SARS-CoV-2, the agent responsible for the COVID-19 pandemic, and a seasonal human β-coronavirus, HCoV-OC43, can be suppressed by depletion of nuclear RNA methyltransferase METTL3 or cytoplasmic m6A reader proteins YTHDF1 and YTHDF3 and by a highly specific small molecule METTL3 inhibitor. Their findings establish that coronavirus RNAs are m6A-modified and host m6A pathway components control β-coronavirus replication, and illustrate the therapeutic potential of inhibiting METTL3 to restrict coronavirus reproduction.