학술논문
Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial
Document Type
Article
Author
Pogorzelski, David; Nguyen, Uyen; McKay, Paula; Thabane, Lehana; Camara, Megan; Ramsey, Lolita; Seymour, Rachel; Goodman, J. Brett; McGee, Sheketha; Fraifogl, Joanne; Hudgins, Andrea; Tanner, Stephanie L.; Bhandari, Mohit; Slobogean, Gerard P.; Sprague, Sheila; Slobogean, Gerard P.; Sprague, Sheila; Wells, Jeffrey; Bhandari, Mohit; Slobogean, Gerard P.; Bhandari, Mohit; Sprague, Sheila; D'Alleyrand, Jean-Claude; Harris, Anthony D.; Mullins, Daniel C.; Thabane, Lehana; Wells, Jeffrey; Wood, Amber; Della Rocca, Gregory J.; Harris, Anthony D.; Hebden, Joan; Jeray, Kyle J.; Marchand, Lucas; O'Hara, Lyndsay M.; Zura, Robert; Gardner, Michael J.; Blasman, Jenna; Davies, Jonah; Liang, Stephen; Taljaard, Monica; Devereaux, P.J.; Guyatt, Gordon H.; Thabane, Lehana; Heels-Ansdell, Diane; Marvel, Debra; Palmer, Jana; Wells, Jeffrey; Friedrich, Jeff; Mullins, Daniel C.; O'Hara, Nathan N.; Grissom, Ms. Frances; Della Rocca, Gregory J.; Gitajn, I. Leah; Jeray, Kyle J.; Morshed, Saam; O'Toole, Robert V.; Petrisor, Bradley A.; Camara, Megan; Mossuto, Franca; Harris, Anthony D.; Joshi, Manjari G.; D'Alleyrand, Jean-Claude; Fowler, Justin; Rivera, Jessica; Talbot, Max; Sprague, Sheila; Bhandari, Mohit; Dodds, Shannon; Garibaldi, Alisha; Li, Silvia; Nguyen, Uyen; Pogorzelski, David; Rojas, Alejandra; Scott, Taryn; Del Fabbro, Gina; Szasz, Olivia Paige; Heels-Ansdell, Diane; McKay, Paula; Slobogean, Gerard P.; O'Hara, Nathan N.; Howe, Andrea; Rudnicki, Joshua; Demyanovich, Haley; Little, Kelly; Mullins, C. Daniel; Medeiros, Michelle; Kettering, Eric; Hale, Diamond; O'Toole, Robert V.; D'Alleyrand, Jean-Claude; Eglseder, Andrew; Johnson, Aaron; Langhammer, Christopher; Lebrun, Christopher; Manson, Theodore; Nascone, Jason; Paryavi, Ebrahim; Pensy, Raymond; Pollak, Andrew; Sciadini, Marcus; Slobogean, Gerard P.; Degani, Yasmin; Demyanovich, Haley K.; Howe, Andrea; O'Hara, Nathan N.; Joseph, Katherine; Rudnicki, Joshua; Camara, Megan; Petrisor, Brad A.; Johal, Herman; Ristevski, Bill; Williams, Dale; Denkers, Matthew; Rajaratnam, Krishan; Al-Asiri, Jamal; Leonard, Jordan; Marcano-Fernández, Francesc A.; Gallant, Jodi; Persico, Federico; Gjorgjievski, Marko; George, Annie; Natoli, Roman M.; Gaski, Greg E.; McKinley, Todd O.; Virkus, Walter W.; Sorkin, Anthony T.; Szatkowski, Jan P.; Baele, Joseph R.; Mullis, Brian H.; Hill, Lauren C.; Hudgins, Andrea; Osborn, Patrick; Fowler, Justin; Pierrie, Sarah; Martinez, Eric; Kimmel, Joseph; Jeray, Kyle J.; Adams, John D.; Beckish, Michael L.; Bray, Christopher C.; Brown, Timothy R.; Cross, Andrew W.; Dew, Timothy; Faucher, Gregory K.; Gurich, Richard W.; Lazarus, David E.; Millon, S. John; Palmer, M. Jason; Porter, Scott E.; Schaller, Thomas M.; Sridhar, Michael S.; Sanders, John L.; Rudisill, L. Edwin; Garitty, Michael J.; Poole, Andrew S.; Sims, Michael L.; Walker, Clark M.; Carlisle, Robert M.; Hofer, Erin Adams; Huggins, Brandon S.; Hunter, Michael D.; Marshall, William A.; Ray, Shea Bielby; Smith, Cory D.; Altman, Kyle M.; Bedard, Julia C.; Loeffler, Markus F.; Pichiotino, Erin R.; Cole, Austin A.; Maltz, Ethan J.; Parker, Wesley; Ramsey, T. Bennett; Burnikel, Alex; Colello, Michael; Stewart, Russell; Wise, Jeremy; Moody, M. Christian; Tanner, Stephanie L.; Snider, Rebecca G.; Townsend, Christine E.; Pham, Kayla H.; Martin, Abigail; Robertson, Emily; Morshed, Saam; Miclau, Theodore; Kandemir, Utku; Marmor, Meir; Matityahu, Amir; McClellan, R. Trigg; Meinberg, Eric; Shearer, David; Toogood, Paul; Ding, Anthony; Donohue, Erin; Belaye, Tigist; Berhaneselase, Eleni; Paul, Alexandra; Garg, Kartik; Gary, Joshua L.; Warner, Stephen J.; Munz, John W.; Choo, Andrew M.; Achor, Timothy S.; “Chip” Routt, Milton L.; Rao, Mayank; Pechero, Guillermo; Miller, Adam; Hagen, Jennifer E.; Patrick, Matthew; Vlasak, Richard; Krupko, Thomas; Sadasivan, Kalia; Koenig, Chris; Bailey, Daniel; Wentworth, Daniel; Van, Chi; Schwartz, Justin; Dehghan, Niloofar; Jones, Clifford B.; Watson, J Tracy; McKee, Michael; Karim, Ammar; Talerico, Michael; Sietsema, Debra L.; Williams, Alyse; Dykes, Tayler; Obremskey, William T.; Jahangir, Amir Alex; Sethi, Manish; Boyce, Robert; Stinner, Daniel J.; Mitchell, Phillip; Trochez, Karen; Rodriguez, Andres; Gajari, Vamshi; Rodriguez, Elsa; Pritchett, Charles; Boulton, Christina; Lowe, Jason; Wild, Jason; Ruth, John T.; Taylor, Michel; Seach, Andrea; Saeed, Sabina; Culbert, Hunter; Cruz, Alejandro; Knapp, Thomas; Hurkett, Colin; Lowney, Maya; Prayson, Michael; Venkatarayappa, Indresh; Horne, Brandon; Jerele, Jennifer; Clark, Linda; Marcano-Fernández, Francesc; Jornet-Gibert, Montsant; Martínez-Carreres, Laia; Martí-Garín, David; Serrano-Sanz, Jorge; Sánchez-Fernández, Joel; Sanz-Molero, Matsuyama; Carballo, Alejandro; Pelfort, Xavier; Acerboni-Flores, Francesc; Alavedra-Massana, Anna; Anglada-Torres, Neus; Berenguer, Alexandre; Cámara-Cabrera, Jaume; Caparros-García, Ariadna; Fillat-Gomà, Ferran; Fuentes-López, Ruben; Garcia-Rodriguez, Ramona; Gimeno-Calavia, Nuria; Graells-Alonso, Guillem; Martínez-Álvarez, Marta; Martínez-Grau, Patricia; Pellejero-García, Raúl; Ràfols-Perramon, Ona; Peñalver, Juan Manuel; Domènech, Mònica Salomó; Soler-Cano, Albert; Velasco-Barrera, Aldo; Yela-Verdú, Christian; Bueno-Ruiz, Mercedes; Sánchez-Palomino, Estrella; Guerra, Ernesto; García, Yaiza; Romeo, Nicholas M.; Vallier, Heather A.; Breslin, Mary A.; Fraifogl, Joanne; Wilson, Eleanor S.; Wadenpfuhl, Leanne K.; Halliday, Paul G.; Viskontas, Darius G.; Apostle, Kelly L.; Boyer, Dory S.; Moola, Farhad O.; Perey, Bertrand H.; Stone, Trevor B.; Lemke, H. Michael; Zomar, Mauri; Spicer, Ella; Fan, Chen “Brenda”; Payne, Kyrsten; Phelps, Kevin; Bosse, Michael; Karunakar, Madhav; Kempton, Laurence; Sims, Stephen; Hsu, Joseph; Seymour, Rachel; Churchill, Christine; Bartel, Claire; Mayberry, Robert Miles; Brownrigg, Maggie; Girardi, Cara; Mayfield, Ada; Hymes, Robert A.; Schwartzbach, Cary C.; Schulman, Jeff E.; Malekzadeh, A. Stephen; Holzman, Michael A.; Ramsey, Lolita; Ahn, James S.; Panjshiri, Farhanaz; Das, Sharmistha; English, Antoinisha D.; Haaser, Sharon M.; Cuff, Jaslynn A.N.; Pilson, Holly; Carroll, Eben A.; Halvorson, Jason J.; Babcock, Sharon; Goodman, J. Brett; Holden, Martha B.; Bullard, Debra; Williams, Wendy; Higgins, Thomas F.; Haller, Justin M.; Rothberg, David L.; Neese, Ashley; Russell, Mark; Gitajn, I. Leah; Coe, Marcus; Dwyer, Kevin; Mullin, Devin S.; Reilly, Clifford A.; DePalo, Peter; Hall, Amy E.; Heng, Marilyn; Harris, Mitchel B.; Smith, R. Malcolm; Lhowe, David W.; Esposito, John G.; Bansal, Mira; Bergin, Patrick F.; Russell, George V.; Graves, Matthew L.; Morellato, John; Champion, Heather K.; Johnson, Leslie N.; McGee, Sheketha L.; Bhanat, Eldrin L.; Mehta, Samir; Donegan, Derek; Ahn, Jaimo; Horan, Annamarie; Dooley, Mary; Kuczinski, Ashley; Iwu, Ashley; Potter, David; VanDemark, Robert; Pfaff, Branden; Hollinsworth, Troy; Weaver, Michael J.; von Keudell, Arvind G.; McTague, Michael F.; Allen, Elizabeth M.; Jaeblon, Todd; Beer, Robert; Demyanovich, Haley K.; Gage, Mark J.; Reilly, Rachel M.; Sparrow, Cindy
Source
Contemporary Clinical Trials Communications; 20210101, Issue: Preprints
Subject
Language
ISSN
24518654
Abstract
Pragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice. They are characterized by broad eligibility criteria and large sample sizes, which can lead to an unmanageable number of participants, increasing the risk of bias and affecting the integrity of the trial. We describe the development of a sampling strategy tool and its use in the PREPARE trial to circumvent the challenge of unmanageable work flow.