학술논문
An in vitrostudy of the effects of Phellodendronbark extract and berberine chloride on periodontal pathogenic bacteria in the oral microbiome
Document Type
Article
Author
Source
Journal of Oral Biosciences; 20220101, Issue: Preprints
Subject
Language
ISSN
13490079
Abstract
Periodontal disease is triggered by oral microbiome dysbiosis. Thus, to prevent its onset, it is important to maintain relative abundance of periodontal pathogenic bacteria in the oral microbiome at a low level. While Phellodendronbark extract (PBE) and its active ingredient, berberine, exert antibacterial effects on periodontal pathogenic bacteria, such as Porphyromonas gingivalis, their effects on the oral microbiome as a whole remain unknown. Therefore, we aimed to clarify the potential of PBE and berberine chloride (BC) in regulating the relative abundance of periodontal pathogenic bacteria in the oral microbiome.