부산대학교 도서관

Background and aims: To detect 1- the prevalence of severe retinopathy of prematurity (> stage 2 - International classification of ROP) among infants = 32 weeks of gestation. 2- The risk factors that are associated with severe ROP.Methods: A retrospective study on infants = 32 weeks born between January 2007 and October 2009 at the King Fahd Armed Forces Hospital of Jeddah in Saudi Arabia. Ophthalmologic examinations as per AAP recommendation was carried till resolution.Results: There were 218 infants = 32wks, the rate of ROP>2 was 14.3% of whom: 48.3% had plus disease, 55.1% had laser and 4.4% expired prior to discharge. Birth-weight(BW) and gestationalage(GA): 1444±385 vs 872±206 and 32.2±2 vs 26.7±2 among ROP>2 and No-ROP respectively, p< 0.0001 None of the exclusively breast fed had (12%) had ROP>2. Post-natal growth differences between ROP>2 vs No-ROP was clinically and statistically insignificant. 86% of ROP>2 had mechanical ventilation, p<.001. Among the 12 infants requiring HFOV, 83.3% had ROP>2, p<.0001. 76% of ROP>2 were on CPAP. BPD occurred among 32 infants; 48.3% had ROP >II, p<.0001. Eight infants required respiratory support at 36 wks PMA, 5 (63%) had ROP>II, p<.002. Positive culture sepsis occurred among 37.9% of ROP>2. 52% of ROP>2 received blood transfusion, p<.02. There was no statistical significant relation between IVH=III, PVL, Hydrocephalus, NEC, PDA, LOS and ROP>2.Conclusion: Exclusive breast feeding seems to be protective of severe ROP. Post-natal growth was not a risk factor however, GA, BW and ventilation were the major determinant of severe ROP.