학술논문
High frequency of N-ras activation in acute myelogenous leukemia
Document Type
Article
Author
Source
Blood; March 1986, Vol. 67 Issue: 3 p753-757, 5p
Subject
Language
ISSN
00064971; 15280020
Abstract
Using the NIH/3T3 cell transfection assay, activated cellular oncogenes have been detected in around 10% to 20% of human tumors. From a series of DNA preparations from tissues infiltrated with acute myelogenous leukemia (AML), 50% (3/6) caused transformation of NIH/3T3 cells. Thus AML appears to be the human tumor with the highest frequency of oncogenes detected by DNA transfection. In each case the oncogene involved was N-ras, a member of the ras gene family. Biologic and clinical parameters of AML patients with and without N-ras oncogenes in their tumors are discussed.