학술논문
Specific human B lymphocyte alloantigens linked to HL-A.
Document Type
Article
Author
Source
Proceedings of the National Academy of Sciences of the United States of America; December 1975, Vol. 72 Issue: 12 p5103-5106, 4p
Subject
Language
ISSN
00278424; 10916490
Abstract
Sera, previously found to react specifically with B lymphoid cultured cells, were tested on isolated T and B peripheral blood lymphocytes in a microcytotoxicity assay. Studies were performed on lymphocytes obtained from several large Amish families. The sera used in these studies were cytotoxic to peripheral blood, B lymphocytes, but not cytotoxic to T lymphocytes. The antigens detected followed the inheritance pattern of HL-A haplotypes. The strong linkage disequilibrium with HL-A antigens suggests that genes controlling the expression of B lymphocyte antigens are linked to genes controlling HL-A alloantigens.