학술논문
Caveolin-1 Knockout Mice Have Increased Bone Size and Stiffness.
Document Type
Article
Author
Source
Journal of Bone & Mineral Research; Sep2007, Vol. 22 Issue 9, p1408-1418, 11p, 4 Charts, 6 Graphs
Subject
Language
ISSN
08840431
Abstract
The study examines the improved bone size and stiffness in mice without the caveolin-1-/- gene. Researchers studied the bones of mice using μCT imaging and mechanical testing. Increased trabecular and cortical bone volume, and increased femural bone strength were observed. The study concluded that caveolin-1-/- deficiency caused rapid bone development by maintaining a low differentiation rate in osteoblast progenitors.