학술논문
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.
Document Type
Article
Author
Dongryeol Ryu; Hongbo Zhang; Ropelle, Eduardo R.; Sorrentino, Vincenzo; Mázala, Davi A. G.; Mouchiroud, Laurent; Marshall, Philip L.; Campbell, Matthew D.; Ali, Amir Safi; Knowels, Gary M.; Bellemin, Stéphanie; Iyer, Shama R.; Xu Wang; Gariani, Karim; Sauve, Anthony A.; Cantó, Carles; Conley, Kevin E.; Walter, Ludivine; Lovering, Richard M.; Chin, Eva R.
Source
Science Translational Medicine; 10/19/2016, Vol. 8 Issue 361, p1-14, 14p, 6 Graphs
Subject
Language
ISSN
19466234
Abstract
The article discusses a study which found that nicotinamide adenine dinucleotide (NAD+ ) repletion is effective in improving muscle function in neuromuscular diseases like Duchene's muscular dystrophy (DMD) and delay both age-related and mdx muscle stem cell senescence. In the mice study, the correlations between the abundance of messenger ribonucleic acid (mRNA) transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and NAD+ were observed.