학술논문
An experimental design for judging synergism on consideration to endocrine disruptor animal experiments.
Document Type
Article
Source
Environmetrics; Feb2009, Vol. 20 Issue 1, p1-13, 13p
Subject
Language
ISSN
11804009
Abstract
The article discusses a study which investigated an appropriate statistical design for an animal experiment to evaluate synergism on consideration to endocrine disruptor. It identifies a statistical design by the set of group size for each combination of doses. It also discusses that the power of t-test to detect synergism by positive surplus of response on a simultaneous administration group from the additivity plane composed of the responses on single administration groups is adopted as the criterion for the appropriate design. It reveals that the dose level of the simultaneous administration group should be located inside or on the boundary of a triangular region and that the total number of animals should be the same as those for single administration groups.